Probable ATP-dependent RNA helicase DDX47 is an
enzyme that in humans is encoded by the DDX47gene.[5]
This gene encodes a member of the
DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative
RNA helicases. They are implicated in a number of
cellular processes involving alteration of RNA secondary structure, such as
translation initiation,
nuclear and
mitochondrialsplicing, and
ribosome and
spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in
embryogenesis,
spermatogenesis, and
cellular growth and
division. The protein encoded by this gene can shuttle between the nucleus and the
cytoplasm, and has an RNA-independent
ATPase activity. Two alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene.[5]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Lee JH, Rho SB, Chun T (2005). "GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)". Biotechnol. Lett. 27 (9): 623–8.
doi:
10.1007/s10529-005-3628-2.
PMID15977068.
S2CID19960329.
Probable ATP-dependent RNA helicase DDX47 is an
enzyme that in humans is encoded by the DDX47gene.[5]
This gene encodes a member of the
DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative
RNA helicases. They are implicated in a number of
cellular processes involving alteration of RNA secondary structure, such as
translation initiation,
nuclear and
mitochondrialsplicing, and
ribosome and
spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in
embryogenesis,
spermatogenesis, and
cellular growth and
division. The protein encoded by this gene can shuttle between the nucleus and the
cytoplasm, and has an RNA-independent
ATPase activity. Two alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene.[5]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Lee JH, Rho SB, Chun T (2005). "GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)". Biotechnol. Lett. 27 (9): 623–8.
doi:
10.1007/s10529-005-3628-2.
PMID15977068.
S2CID19960329.