Doublecortin domain-containing protein 2 (DCDC2) is a
protein that in humans is encoded by the DCDC2gene.[5][6][7]
Function
This gene encodes a protein with two
doublecortin peptide domains. This domain has been demonstrated to bind
tubulin and enhance microtubule polymerization.[7]
Clinical significance
Mutations in this gene have been associated with
reading disability (RD), also referred to as
developmental dyslexia.[7][8] But this is controverse since a recent study proposed that there is a "low likelihood of a direct deletion effect on reading skills."[9]
Changes in the DCDC2 gene are frequently found among dyslexics. Altered
alleles often occur among children with
reading and
writing difficulties. The gene appears to have a strong linkage with the processing of speech information when writing.[10][11][12]
Brkanac Z, Chapman NH, Matsushita MM, et al. (2007). "Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 556–60.
doi:
10.1002/ajmg.b.30471.
PMID17450541.
S2CID43864328.
Doublecortin domain-containing protein 2 (DCDC2) is a
protein that in humans is encoded by the DCDC2gene.[5][6][7]
Function
This gene encodes a protein with two
doublecortin peptide domains. This domain has been demonstrated to bind
tubulin and enhance microtubule polymerization.[7]
Clinical significance
Mutations in this gene have been associated with
reading disability (RD), also referred to as
developmental dyslexia.[7][8] But this is controverse since a recent study proposed that there is a "low likelihood of a direct deletion effect on reading skills."[9]
Changes in the DCDC2 gene are frequently found among dyslexics. Altered
alleles often occur among children with
reading and
writing difficulties. The gene appears to have a strong linkage with the processing of speech information when writing.[10][11][12]
Brkanac Z, Chapman NH, Matsushita MM, et al. (2007). "Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 556–60.
doi:
10.1002/ajmg.b.30471.
PMID17450541.
S2CID43864328.