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| Clinical data | |
|---|---|
| Other names | Neurosterone; 6β-Hydroxy-3:5-cyclopregnan-20-one |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C21H32O2 |
| Molar mass | 316.485 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
Cyclopregnol ( INN), also known as neurosterone, as well as 6β-hydroxy-3:5-cyclopregnan-20-one, is a synthetic pregnane steroid which was developed in the 1950s as a " psychotropic agent" for the treatment of mental disorders but was never marketed. [1] [2] [3] [4] Although an initial small clinical study found effectiveness, [3] a subsequent, larger and more rigorous study found that cyclopregnol was no more effective than placebo and was clearly inferior to chlorpromazine. [4] [5]
See also
References
- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 646–. ISBN 978-1-4757-2085-3.
- ^ Patel DK, Petrow V, Stuart-Webb IA (1957). "133. 6β-Hydroxy-3 : 5-cyclopregnan-20-one and some related compounds". J. Chem. Soc.: 665–668. doi: 10.1039/JR9570000665. ISSN 0368-1769.
- ^ a b Hardwick SW, Pearse JJ, Petrow V (October 1957). "6 beta-Hydroxy-3:5-cyclopregnan-20-one in mental states". The Journal of Mental Science. 103 (433): 835–839. doi: 10.1192/bjp.103.433.835. PMID 13481595.
- ^ a b Loranger AW (July 1968). "Treatment of acute mental disorders with an adrenal steroid". The British Journal of Psychiatry. 114 (512): 843–844. doi: 10.1192/bjp.114.512.843. PMID 4874165. S2CID 45608631.
- ^ Pachter IJ, Rubin AA (1969). "Antipyschotic and Anti-anxiety Agents". In Childress SJ D (ed.). Annual Reports in Medicinal Chemistry. Academic Press. pp. 3–. ISBN 978-0-08-058348-8.
 | This article about a steroid is a stub. You can help Wikipedia by expanding it. |
 | This psychoactive drug-related article is a stub. You can help Wikipedia by expanding it. |
|
| |
| Clinical data | |
|---|---|
| Other names | Neurosterone; 6β-Hydroxy-3:5-cyclopregnan-20-one |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C21H32O2 |
| Molar mass | 316.485 g·mol−1 |
| 3D model ( JSmol) | |
| |
| |
Cyclopregnol ( INN), also known as neurosterone, as well as 6β-hydroxy-3:5-cyclopregnan-20-one, is a synthetic pregnane steroid which was developed in the 1950s as a " psychotropic agent" for the treatment of mental disorders but was never marketed. [1] [2] [3] [4] Although an initial small clinical study found effectiveness, [3] a subsequent, larger and more rigorous study found that cyclopregnol was no more effective than placebo and was clearly inferior to chlorpromazine. [4] [5]
See also
References
- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 646–. ISBN 978-1-4757-2085-3.
- ^ Patel DK, Petrow V, Stuart-Webb IA (1957). "133. 6β-Hydroxy-3 : 5-cyclopregnan-20-one and some related compounds". J. Chem. Soc.: 665–668. doi: 10.1039/JR9570000665. ISSN 0368-1769.
- ^ a b Hardwick SW, Pearse JJ, Petrow V (October 1957). "6 beta-Hydroxy-3:5-cyclopregnan-20-one in mental states". The Journal of Mental Science. 103 (433): 835–839. doi: 10.1192/bjp.103.433.835. PMID 13481595.
- ^ a b Loranger AW (July 1968). "Treatment of acute mental disorders with an adrenal steroid". The British Journal of Psychiatry. 114 (512): 843–844. doi: 10.1192/bjp.114.512.843. PMID 4874165. S2CID 45608631.
- ^ Pachter IJ, Rubin AA (1969). "Antipyschotic and Anti-anxiety Agents". In Childress SJ D (ed.). Annual Reports in Medicinal Chemistry. Academic Press. pp. 3–. ISBN 978-0-08-058348-8.
|
| This article about a steroid is a stub. You can help Wikipedia by expanding it. |
|
| This psychoactive drug-related article is a stub. You can help Wikipedia by expanding it. |