CsrB/RsmB RNA family | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of CsrB | |
Identifiers | |
Symbol | CsrB |
Rfam | RF00018 |
Other data | |
RNA type | Gene; sRNA |
Domain(s) | Bacteria |
SO | SO:0000377 |
PDB structures | PDBe |
The CsrB RNA is a non-coding RNA that binds to approximately 9 to 10 dimers of the CsrA protein. [1] The CsrB RNAs contain a conserved motif CAGGXXG that is found in up to 18 copies and has been suggested to bind CsrA. The Csr regulatory system has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. [2] In other bacteria such as Erwinia carotovora the RsmA protein has been shown to regulate the production of virulence determinants, such extracellular enzymes. [3] RsmA binds to RsmB regulatory RNA which is also a member of this family.
RsmB RNA was shown to be upregulated by GacS/A system, and increase downstream T3SS gene expression. [4] FlhDC, the master regulator of flagellar genes, also activates rsmB RNA production. [5] A regulatory network have been revealed connecting rsmB, FlhDC and T3SS. [6]
It has been shown to play role in the biocontrol activity of Rahnella aquatilis HX2 (a biocontrol agent producing antibacterial substance). [7]
CsrB/RsmB RNA family | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of CsrB | |
Identifiers | |
Symbol | CsrB |
Rfam | RF00018 |
Other data | |
RNA type | Gene; sRNA |
Domain(s) | Bacteria |
SO | SO:0000377 |
PDB structures | PDBe |
The CsrB RNA is a non-coding RNA that binds to approximately 9 to 10 dimers of the CsrA protein. [1] The CsrB RNAs contain a conserved motif CAGGXXG that is found in up to 18 copies and has been suggested to bind CsrA. The Csr regulatory system has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. [2] In other bacteria such as Erwinia carotovora the RsmA protein has been shown to regulate the production of virulence determinants, such extracellular enzymes. [3] RsmA binds to RsmB regulatory RNA which is also a member of this family.
RsmB RNA was shown to be upregulated by GacS/A system, and increase downstream T3SS gene expression. [4] FlhDC, the master regulator of flagellar genes, also activates rsmB RNA production. [5] A regulatory network have been revealed connecting rsmB, FlhDC and T3SS. [6]
It has been shown to play role in the biocontrol activity of Rahnella aquatilis HX2 (a biocontrol agent producing antibacterial substance). [7]