Cruentarens are a group of macrolides secreted by the myxobacteria Byssovorax cruenta. [1] There are two isomers (cruentaren A and B) have been isolated. [2] They each have a molecular formula of C33H51NO8 and molecular weight 589 g/mol. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro, [3] including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.
Cruentarens are a group of macrolides secreted by the myxobacteria Byssovorax cruenta. [1] There are two isomers (cruentaren A and B) have been isolated. [2] They each have a molecular formula of C33H51NO8 and molecular weight 589 g/mol. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro, [3] including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.