Crc | |||||||||
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![]() Crystal structure of Crc in Pseudomonas aeruginosa.
[1] | |||||||||
Identifiers | |||||||||
Symbol | Crc | ||||||||
Pfam | PF03372 | ||||||||
CDD | cd08372 | ||||||||
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The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. [2] Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted. [3] Crc-mediated regulation impact processes such as biofilm formation, [4] virulence [5] and antibiotic susceptibility. [6]
Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation. [7]
Crc | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() Crystal structure of Crc in Pseudomonas aeruginosa.
[1] | |||||||||
Identifiers | |||||||||
Symbol | Crc | ||||||||
Pfam | PF03372 | ||||||||
CDD | cd08372 | ||||||||
|
The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. [2] Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted. [3] Crc-mediated regulation impact processes such as biofilm formation, [4] virulence [5] and antibiotic susceptibility. [6]
Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation. [7]