Combined rapid anterior pituitary evaluation panel | |
---|---|
OPS-301 code | 1-797 |
A combined rapid anterior pituitary evaluation panel or triple bolus test or a dynamic pituitary function test is a medical diagnostic procedure used to assess a patient's pituitary function. A triple bolus test is usually ordered and interpreted by endocrinologists.[ citation needed]
In rare cases, it has been associated with pituitary apoplexy. [1]
Three hormones [2] (usually synthetic analogues) are injected as a bolus into the patient's vein to stimulate the anterior pituitary gland:
The gland's response is assessed by measuring the rise in cortisol and growth hormone (GH) in response to the hypoglycaemia caused by insulin, rises in prolactin and thyroid-stimulating hormone (TSH) caused by TRH and rises in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) caused by GnRH. Blood glucose levels are also monitored to ensure appropriate levels of hypoglycemia are achieved.[ citation needed]
The triple bolus test was introduced in 1973 by physicians from the London Royal Postgraduate Medical School and Queen Elizabeth Hospital, Birmingham. [3] It followed earlier reports combining insulin and vasopressin analogues in the diagnosis of hypopituitarism. [4]
Combined rapid anterior pituitary evaluation panel | |
---|---|
OPS-301 code | 1-797 |
A combined rapid anterior pituitary evaluation panel or triple bolus test or a dynamic pituitary function test is a medical diagnostic procedure used to assess a patient's pituitary function. A triple bolus test is usually ordered and interpreted by endocrinologists.[ citation needed]
In rare cases, it has been associated with pituitary apoplexy. [1]
Three hormones [2] (usually synthetic analogues) are injected as a bolus into the patient's vein to stimulate the anterior pituitary gland:
The gland's response is assessed by measuring the rise in cortisol and growth hormone (GH) in response to the hypoglycaemia caused by insulin, rises in prolactin and thyroid-stimulating hormone (TSH) caused by TRH and rises in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) caused by GnRH. Blood glucose levels are also monitored to ensure appropriate levels of hypoglycemia are achieved.[ citation needed]
The triple bolus test was introduced in 1973 by physicians from the London Royal Postgraduate Medical School and Queen Elizabeth Hospital, Birmingham. [3] It followed earlier reports combining insulin and vasopressin analogues in the diagnosis of hypopituitarism. [4]