![]() | |
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C6H6N2O2 |
Molar mass | 138.126 g·mol−1 |
3D model ( JSmol) | |
| |
|
cis-Urocanic acid (cis-UCA) is a chemical compound produced by ultraviolet irradiation of trans-urocanic acid, a metabolite naturally formed in the body from histidine. cis-Urocanic acid is suspected of involvement in the development of skin cancer. It acts as an immunosuppressant through action as an agonist of the 5-HT2A receptor, and blocking this receptor has been shown to reduce cis-UCA mediated photocarcinogenesis. [1] [2] [3] However the immunomodulatory effects of cis-UCA are complex and also involve other pathways, and at low levels it shows antiinflammatory actions and may be protective against UV damage in the cornea and retina. [4] [5] [6] [7] [8] [9]
![]() | |
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C6H6N2O2 |
Molar mass | 138.126 g·mol−1 |
3D model ( JSmol) | |
| |
|
cis-Urocanic acid (cis-UCA) is a chemical compound produced by ultraviolet irradiation of trans-urocanic acid, a metabolite naturally formed in the body from histidine. cis-Urocanic acid is suspected of involvement in the development of skin cancer. It acts as an immunosuppressant through action as an agonist of the 5-HT2A receptor, and blocking this receptor has been shown to reduce cis-UCA mediated photocarcinogenesis. [1] [2] [3] However the immunomodulatory effects of cis-UCA are complex and also involve other pathways, and at low levels it shows antiinflammatory actions and may be protective against UV damage in the cornea and retina. [4] [5] [6] [7] [8] [9]