Home • Search • Translate
Photos • Biography • Facebook • Twitter

From Wikipedia, the free encyclopedia

Chris Ponting
Born
Christopher Paul Ponting
NationalityBritish
Alma mater
Known forSMART [1]
Scientific career
Fields
Institutions University of Edinburgh
Thesis Structural Studies of Plasminogen and Related Proteins (1992)
Website www.ed.ac.uk/mrc-human-genetics-unit/research/ponting-group

Christopher Paul Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Chair of Medical Bioinformatics at the University of Edinburgh and group leader in the MRC Human Genetics Unit. He is also an Associate Faculty member of the Wellcome Trust Sanger Institute, a Fellow of the Academy of Medical Sciences, member of the European Molecular Biology Organisation and Fellow of the Royal Society of Edinburgh. [2] His research focuses on long noncoding RNA function and evolution, on single cell biology and on disease genomics. [3] [4] [5] [6] [7] [8] Outside of science, Chris is an amateur novelist and wrote an unpublished, science fiction novel about engineered viruses. [9]

Education

After receiving his Bachelor of Arts and Master of Science in physics from University of Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his Doctor of Philosophy in biophysics in 1992 on structural studies of plasminogen. [10] [11]

Research

Ponting contributed to the Human Genome Project, [12] and participated in sequence comparison for the mouse, [13] rat, [14] chicken, [15] dog, [16] opossum, [17] and platypus [18] [19] [20] Genome Projects. He has also used comparative genomics to contribute directly to the understanding of chromatin structure [21] and the genetics of numerous conditions including asthma, [22] obesity, [23] Alzheimer's disease, [24] retinitis pigmentosa, [25] muscular dystrophies, [26] and Aicardi–Goutières syndrome. [27]

Additionally, his lab is part of DecodeME, a genetic study to determine the potential causes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). [28] [9]

References

  1. ^ Schultz, J.; Milpetz, F.; Bork, P.; Ponting, C. (1998). "SMART, a simple modular architecture research tool: Identification of signaling domains". Proceedings of the National Academy of Sciences of the United States of America. 95 (11): 5857–5864. Bibcode: 1998PNAS...95.5857S. doi: 10.1073/pnas.95.11.5857. PMC  34487. PMID  9600884.
  2. ^ "Professor Christopher Paul Ponting FMedSci FRSE - The Royal Society of Edinburgh". The Royal Society of Edinburgh. Retrieved 14 March 2018.
  3. ^ Chris Ponting's publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ Sims, David (2014). "Sequencing depth and coverage: key considerations in genomic analyses". Nature Reviews Genetics. 15 (2): 121–132. doi: 10.1038/nrg3642. PMID  24434847. S2CID  13325739.
  5. ^ Rands, Chris M. (2014). "8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage". PLOS Genetics. 10 (7): e1004525. doi: 10.1371/journal.pgen.1004525. PMC  4109858. PMID  25057982.
  6. ^ Gibbs, R. A.; Weinstock, G. M.; Metzker, M. L.; Muzny, D. M.; Sodergren, E. J.; Scherer, S; Scott, G; Steffen, D; Worley, K. C.; Burch, P. E.; Okwuonu, G; Hines, S; Lewis, L; Deramo, C; Delgado, O; Dugan-Rocha, S; Miner, G; Morgan, M; Hawes, A; Gill, R; Celera; Holt, R. A.; Adams, M. D.; Amanatides, P. G.; Baden-Tillson, H; Barnstead, M; Chin, S; Evans, C. A.; Ferriera, S; et al. (2004). "Genome sequence of the Brown Norway rat yields insights into mammalian evolution". Nature. 428 (6982): 493–521. Bibcode: 2004Natur.428..493G. doi: 10.1038/nature02426. PMID  15057822.
  7. ^ Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. Bibcode: 2007Natur.450..203C. doi: 10.1038/nature06341. PMID  17994087.{{ cite journal}}: CS1 maint: numeric names: authors list ( link)
  8. ^ Mulder, N. J.; Apweiler, R; Attwood, T. K.; Bairoch, A; Barrell, D; Bateman, A; Binns, D; Biswas, M; Bradley, P; Bork, P; Bucher, P; Copley, R. R.; Courcelle, E; Das, U; Durbin, R; Falquet, L; Fleischmann, W; Griffiths-Jones, S; Haft, D; Harte, N; Hulo, N; Kahn, D; Kanapin, A; Krestyaninova, M; Lopez, R; Letunic, I; Lonsdale, D; Silventoinen, V.; Orchard, S. E.; Pagni, M.; Pagni, Marco; Peyruc, D.; Ponting, C.P.; Selengut, J.D.; Servant, F.; Sigrist, C.J.A.; Vaughan, R.; Zdobnov, E.M. (2003). "The InterPro Database, 2003 brings increased coverage and new features". Nucleic Acids Research. 31 (1): 315–8. doi: 10.1093/nar/gkg046. PMC  165493. PMID  12520011.
  9. ^ a b The Bioinformatics CRO Podcast. Episode 2, 2020.
  10. ^ Ponting, Christopher Paul (1992). Structural Studies of Plasminogen and Related Proteins (DPhil thesis). University of Oxford. OCLC  556763136.
  11. ^ "Prof. Chris P Ponting BA MSc DPhil". University of Oxford. Archived from the original on 7 April 2014.
  12. ^ Lander, E. S.; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (February 2001). "Initial sequencing and analysis of the human genome". Nature. 409 (6822): 860–921. Bibcode: 2001Natur.409..860L. doi: 10.1038/35057062. hdl: 2027.42/62798. ISSN  0028-0836. PMID  11237011.
  13. ^ Chinwalla, A. T.; Waterston, L. L.; Lindblad-Toh, K. D.; Birney, G. A.; Rogers, L. A.; Abril, R. S.; Agarwal, T. A.; Agarwala, L. W.; Ainscough, E. R.; Alexandersson, J. D.; An, T. L.; Antonarakis, W. E.; Attwood, J. O.; Baertsch, M. N.; Bailey, K. H.; Barlow, C. S.; Beck, T. C.; Berry, B.; Birren, J.; Bloom, E.; Bork, R. H.; Botcherby, M. C.; Bray, R. K.; Brent, S. P.; Brown, P.; Brown, E.; Bult, B.; Burton, T.; Butler, D. G.; et al. (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode: 2002Natur.420..520W. doi: 10.1038/nature01262. PMID  12466850.
  14. ^ Amos, Jonathan (31 March 2004). "Rat's 'life code' read by science". BBC News. Retrieved 19 December 2008.
  15. ^ "Chicken gives up genetic secrets". BBC News. 9 December 2004. Retrieved 19 December 2008.
  16. ^ Lindblad-Toh, K.; Wade, C. M.; Mikkelsen, T. S.; Karlsson, E. K.; Jaffe, D. B.; Kamal, M.; Clamp, M.; Chang, J. L.; Kulbokas, E. J.; Zody, M. C.; Mauceli, E.; Xie, X.; Breen, M.; Wayne, R. K.; Ostrander, E. A.; Ponting, C. P.; Galibert, F.; Smith, D. R.; Dejong, P. J.; Kirkness, E.; Alvarez, P.; Biagi, T.; Brockman, W.; Butler, J.; Chin, C. W.; Cook, A.; Cuff, J.; Daly, M. J.; Decaprio, D.; et al. (2005). "Genome sequence, comparative analysis and haplotype structure of the domestic dog". Nature. 438 (7069): 803–819. Bibcode: 2005Natur.438..803L. doi: 10.1038/nature04338. PMID  16341006.
  17. ^ Mikkelsen, T. S.; Wakefield, M. J.; Aken, B.; Amemiya, C. T.; Chang, J. L.; Duke, S.; Garber, M.; Gentles, A. J.; Goodstadt, L.; Heger, A.; Jurka, J.; Kamal, M.; Mauceli, E.; Searle, S. M. J.; Sharpe, T.; Baker, M. L.; Batzer, M. A.; Benos, P. V.; Belov, K.; Clamp, M.; Cook, A.; Cuff, J.; Das, R.; Davidow, L.; Deakin, J. E.; Fazzari, M. J.; Glass, J. L.; Grabherr, M.; Greally, J. M.; et al. (2007). "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences". Nature. 447 (7141): 167–177. Bibcode: 2007Natur.447..167M. doi: 10.1038/nature05805. PMID  17495919.
  18. ^ Warren, W. C.; Hillier, L. W.; Marshall Graves, J. A.; Birney, E.; Ponting, C. P.; Grützner, F.; Belov, K.; Miller, W.; Clarke, L.; Chinwalla, A. T.; Yang, S. P.; Heger, A.; Locke, D. P.; Miethke, P.; Waters, P. D.; Veyrunes, F. D. R.; Fulton, L.; Fulton, B.; Graves, T.; Wallis, J.; Puente, X. S.; López-Otín, C.; Ordóñez, G. R.; Eichler, E. E.; Chen, L.; Cheng, Z.; Deakin, J. E.; Alsop, A.; Thompson, K.; et al. (2008). "Genome analysis of the platypus reveals unique signatures of evolution". Nature. 453 (7192): 175–183. Bibcode: 2008Natur.453..175W. doi: 10.1038/nature06936. PMC  2803040. PMID  18464734.
  19. ^ http://www.nature.com/nature/videoarchive/platypusgenome/ Discussing the platypus genome
  20. ^ Briggs, Helen (7 May 2008). "Platypus genetic code unravelled". BBC News. Retrieved 19 December 2008.
  21. ^ Jenuwein, T.; Eisenhaber, S.; O'Carroll, F.; Strahl, D. N.; Sun, B. D.; Schmid, Z. W.; Opravil, M.; Mechtler, S.; Ponting, K.; Allis, C. P.; Jenuwein, C. D. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–599. Bibcode: 2000Natur.406..593R. doi: 10.1038/35020506. PMID  10949293. S2CID  205008015.
  22. ^ Zhang, Y.; Leaves, N. I.; Anderson, G. G.; Ponting, C. P.; Broxholme, J.; Holt, R.; Edser, P.; Bhattacharyya, S.; Dunham, A.; Adcock, I. M.; Pulleyn, L.; Barnes, P. J.; Harper, J. I.; Abecasis, G. A.; Cardon, L.; White, M.; Burton, J.; Matthews, L.; Mott, R.; Ross, M.; Cox, R.; Moffatt, M. F.; Cookson, W. O. C. M. (2003). "Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma". Nature Genetics. 34 (2): 181–186. doi: 10.1038/ng1166. hdl: 10044/1/57392. PMID  12754510. S2CID  20807679.
  23. ^ Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode: 2007Sci...318.1469G. doi: 10.1126/science.1151710. PMC  2668859. PMID  17991826.
  24. ^ Ponting, C. P.; Hutton, M.; Nyborg, A.; Baker, M.; Jansen, K.; Golde, T. E. (2002). "Identification of a novel family of presenilin homologues". Human Molecular Genetics. 11 (9): 1037–1044. doi: 10.1093/hmg/11.9.1037. PMID  11978763.
  25. ^ Abd El-Aziz, M. M.; Barragan, I.; O'Driscoll, C. A.; Goodstadt, L.; Prigmore, E.; Borrego, S.; Mena, M.; Pieras, J. I.; El-Ashry, M. F.; Safieh, L. A.; Shah, A.; Cheetham, M. E.; Carter, N. P.; Chakarova, C.; Ponting, C. P.; Bhattacharya, S. S.; Antinolo, G. (2008). "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa". Nature Genetics. 40 (11): 1285–1287. doi: 10.1038/ng.241. PMC  2719291. PMID  18836446.
  26. ^ Dickens, N. J.; Beatson, S.; Ponting, C. P. (2002). "Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins". Current Biology. 12 (6): R197–R199. doi: 10.1016/S0960-9822(02)00748-0. PMID  11909544. S2CID  15872294.
  27. ^ Crow, Y. J.; Leitch, A.; Hayward, B. E.; Garner, A.; Parmar, R.; Griffith, E.; Ali, M.; Semple, C.; Aicardi, J.; Babul-Hirji, R.; Baumann, C.; Baxter, P.; Bertini, E.; Chandler, K. E.; Chitayat, D.; Cau, D.; Déry, C.; Fazzi, E.; Goizet, C.; King, M. D.; Klepper, J.; Lacombe, D.; Lanzi, G.; Lyall, H.; Martínez-Frías, M. A. L.; Mathieu, M. L.; McKeown, C.; Monier, A.; Oade, Y.; Quarrell, O. W. (2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature Genetics. 38 (8): 910–916. doi: 10.1038/ng1842. PMID  16845400. S2CID  8076225.
  28. ^ Chris Ponting Research Group MRC Human Genetics Research Unit. July 2021.
Retrieved from " https://en.wikipedia.org/?title=Chris_Ponting&oldid=1203206745"
From Wikipedia, the free encyclopedia

Chris Ponting
Born
Christopher Paul Ponting
NationalityBritish
Alma mater
Known forSMART [1]
Scientific career
Fields
Institutions University of Edinburgh
Thesis Structural Studies of Plasminogen and Related Proteins (1992)
Website www.ed.ac.uk/mrc-human-genetics-unit/research/ponting-group

Christopher Paul Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Chair of Medical Bioinformatics at the University of Edinburgh and group leader in the MRC Human Genetics Unit. He is also an Associate Faculty member of the Wellcome Trust Sanger Institute, a Fellow of the Academy of Medical Sciences, member of the European Molecular Biology Organisation and Fellow of the Royal Society of Edinburgh. [2] His research focuses on long noncoding RNA function and evolution, on single cell biology and on disease genomics. [3] [4] [5] [6] [7] [8] Outside of science, Chris is an amateur novelist and wrote an unpublished, science fiction novel about engineered viruses. [9]

Education

After receiving his Bachelor of Arts and Master of Science in physics from University of Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his Doctor of Philosophy in biophysics in 1992 on structural studies of plasminogen. [10] [11]

Research

Ponting contributed to the Human Genome Project, [12] and participated in sequence comparison for the mouse, [13] rat, [14] chicken, [15] dog, [16] opossum, [17] and platypus [18] [19] [20] Genome Projects. He has also used comparative genomics to contribute directly to the understanding of chromatin structure [21] and the genetics of numerous conditions including asthma, [22] obesity, [23] Alzheimer's disease, [24] retinitis pigmentosa, [25] muscular dystrophies, [26] and Aicardi–Goutières syndrome. [27]

Additionally, his lab is part of DecodeME, a genetic study to determine the potential causes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). [28] [9]

References

  1. ^ Schultz, J.; Milpetz, F.; Bork, P.; Ponting, C. (1998). "SMART, a simple modular architecture research tool: Identification of signaling domains". Proceedings of the National Academy of Sciences of the United States of America. 95 (11): 5857–5864. Bibcode: 1998PNAS...95.5857S. doi: 10.1073/pnas.95.11.5857. PMC  34487. PMID  9600884.
  2. ^ "Professor Christopher Paul Ponting FMedSci FRSE - The Royal Society of Edinburgh". The Royal Society of Edinburgh. Retrieved 14 March 2018.
  3. ^ Chris Ponting's publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ Sims, David (2014). "Sequencing depth and coverage: key considerations in genomic analyses". Nature Reviews Genetics. 15 (2): 121–132. doi: 10.1038/nrg3642. PMID  24434847. S2CID  13325739.
  5. ^ Rands, Chris M. (2014). "8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage". PLOS Genetics. 10 (7): e1004525. doi: 10.1371/journal.pgen.1004525. PMC  4109858. PMID  25057982.
  6. ^ Gibbs, R. A.; Weinstock, G. M.; Metzker, M. L.; Muzny, D. M.; Sodergren, E. J.; Scherer, S; Scott, G; Steffen, D; Worley, K. C.; Burch, P. E.; Okwuonu, G; Hines, S; Lewis, L; Deramo, C; Delgado, O; Dugan-Rocha, S; Miner, G; Morgan, M; Hawes, A; Gill, R; Celera; Holt, R. A.; Adams, M. D.; Amanatides, P. G.; Baden-Tillson, H; Barnstead, M; Chin, S; Evans, C. A.; Ferriera, S; et al. (2004). "Genome sequence of the Brown Norway rat yields insights into mammalian evolution". Nature. 428 (6982): 493–521. Bibcode: 2004Natur.428..493G. doi: 10.1038/nature02426. PMID  15057822.
  7. ^ Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. Bibcode: 2007Natur.450..203C. doi: 10.1038/nature06341. PMID  17994087.{{ cite journal}}: CS1 maint: numeric names: authors list ( link)
  8. ^ Mulder, N. J.; Apweiler, R; Attwood, T. K.; Bairoch, A; Barrell, D; Bateman, A; Binns, D; Biswas, M; Bradley, P; Bork, P; Bucher, P; Copley, R. R.; Courcelle, E; Das, U; Durbin, R; Falquet, L; Fleischmann, W; Griffiths-Jones, S; Haft, D; Harte, N; Hulo, N; Kahn, D; Kanapin, A; Krestyaninova, M; Lopez, R; Letunic, I; Lonsdale, D; Silventoinen, V.; Orchard, S. E.; Pagni, M.; Pagni, Marco; Peyruc, D.; Ponting, C.P.; Selengut, J.D.; Servant, F.; Sigrist, C.J.A.; Vaughan, R.; Zdobnov, E.M. (2003). "The InterPro Database, 2003 brings increased coverage and new features". Nucleic Acids Research. 31 (1): 315–8. doi: 10.1093/nar/gkg046. PMC  165493. PMID  12520011.
  9. ^ a b The Bioinformatics CRO Podcast. Episode 2, 2020.
  10. ^ Ponting, Christopher Paul (1992). Structural Studies of Plasminogen and Related Proteins (DPhil thesis). University of Oxford. OCLC  556763136.
  11. ^ "Prof. Chris P Ponting BA MSc DPhil". University of Oxford. Archived from the original on 7 April 2014.
  12. ^ Lander, E. S.; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (February 2001). "Initial sequencing and analysis of the human genome". Nature. 409 (6822): 860–921. Bibcode: 2001Natur.409..860L. doi: 10.1038/35057062. hdl: 2027.42/62798. ISSN  0028-0836. PMID  11237011.
  13. ^ Chinwalla, A. T.; Waterston, L. L.; Lindblad-Toh, K. D.; Birney, G. A.; Rogers, L. A.; Abril, R. S.; Agarwal, T. A.; Agarwala, L. W.; Ainscough, E. R.; Alexandersson, J. D.; An, T. L.; Antonarakis, W. E.; Attwood, J. O.; Baertsch, M. N.; Bailey, K. H.; Barlow, C. S.; Beck, T. C.; Berry, B.; Birren, J.; Bloom, E.; Bork, R. H.; Botcherby, M. C.; Bray, R. K.; Brent, S. P.; Brown, P.; Brown, E.; Bult, B.; Burton, T.; Butler, D. G.; et al. (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode: 2002Natur.420..520W. doi: 10.1038/nature01262. PMID  12466850.
  14. ^ Amos, Jonathan (31 March 2004). "Rat's 'life code' read by science". BBC News. Retrieved 19 December 2008.
  15. ^ "Chicken gives up genetic secrets". BBC News. 9 December 2004. Retrieved 19 December 2008.
  16. ^ Lindblad-Toh, K.; Wade, C. M.; Mikkelsen, T. S.; Karlsson, E. K.; Jaffe, D. B.; Kamal, M.; Clamp, M.; Chang, J. L.; Kulbokas, E. J.; Zody, M. C.; Mauceli, E.; Xie, X.; Breen, M.; Wayne, R. K.; Ostrander, E. A.; Ponting, C. P.; Galibert, F.; Smith, D. R.; Dejong, P. J.; Kirkness, E.; Alvarez, P.; Biagi, T.; Brockman, W.; Butler, J.; Chin, C. W.; Cook, A.; Cuff, J.; Daly, M. J.; Decaprio, D.; et al. (2005). "Genome sequence, comparative analysis and haplotype structure of the domestic dog". Nature. 438 (7069): 803–819. Bibcode: 2005Natur.438..803L. doi: 10.1038/nature04338. PMID  16341006.
  17. ^ Mikkelsen, T. S.; Wakefield, M. J.; Aken, B.; Amemiya, C. T.; Chang, J. L.; Duke, S.; Garber, M.; Gentles, A. J.; Goodstadt, L.; Heger, A.; Jurka, J.; Kamal, M.; Mauceli, E.; Searle, S. M. J.; Sharpe, T.; Baker, M. L.; Batzer, M. A.; Benos, P. V.; Belov, K.; Clamp, M.; Cook, A.; Cuff, J.; Das, R.; Davidow, L.; Deakin, J. E.; Fazzari, M. J.; Glass, J. L.; Grabherr, M.; Greally, J. M.; et al. (2007). "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences". Nature. 447 (7141): 167–177. Bibcode: 2007Natur.447..167M. doi: 10.1038/nature05805. PMID  17495919.
  18. ^ Warren, W. C.; Hillier, L. W.; Marshall Graves, J. A.; Birney, E.; Ponting, C. P.; Grützner, F.; Belov, K.; Miller, W.; Clarke, L.; Chinwalla, A. T.; Yang, S. P.; Heger, A.; Locke, D. P.; Miethke, P.; Waters, P. D.; Veyrunes, F. D. R.; Fulton, L.; Fulton, B.; Graves, T.; Wallis, J.; Puente, X. S.; López-Otín, C.; Ordóñez, G. R.; Eichler, E. E.; Chen, L.; Cheng, Z.; Deakin, J. E.; Alsop, A.; Thompson, K.; et al. (2008). "Genome analysis of the platypus reveals unique signatures of evolution". Nature. 453 (7192): 175–183. Bibcode: 2008Natur.453..175W. doi: 10.1038/nature06936. PMC  2803040. PMID  18464734.
  19. ^ http://www.nature.com/nature/videoarchive/platypusgenome/ Discussing the platypus genome
  20. ^ Briggs, Helen (7 May 2008). "Platypus genetic code unravelled". BBC News. Retrieved 19 December 2008.
  21. ^ Jenuwein, T.; Eisenhaber, S.; O'Carroll, F.; Strahl, D. N.; Sun, B. D.; Schmid, Z. W.; Opravil, M.; Mechtler, S.; Ponting, K.; Allis, C. P.; Jenuwein, C. D. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–599. Bibcode: 2000Natur.406..593R. doi: 10.1038/35020506. PMID  10949293. S2CID  205008015.
  22. ^ Zhang, Y.; Leaves, N. I.; Anderson, G. G.; Ponting, C. P.; Broxholme, J.; Holt, R.; Edser, P.; Bhattacharyya, S.; Dunham, A.; Adcock, I. M.; Pulleyn, L.; Barnes, P. J.; Harper, J. I.; Abecasis, G. A.; Cardon, L.; White, M.; Burton, J.; Matthews, L.; Mott, R.; Ross, M.; Cox, R.; Moffatt, M. F.; Cookson, W. O. C. M. (2003). "Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma". Nature Genetics. 34 (2): 181–186. doi: 10.1038/ng1166. hdl: 10044/1/57392. PMID  12754510. S2CID  20807679.
  23. ^ Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode: 2007Sci...318.1469G. doi: 10.1126/science.1151710. PMC  2668859. PMID  17991826.
  24. ^ Ponting, C. P.; Hutton, M.; Nyborg, A.; Baker, M.; Jansen, K.; Golde, T. E. (2002). "Identification of a novel family of presenilin homologues". Human Molecular Genetics. 11 (9): 1037–1044. doi: 10.1093/hmg/11.9.1037. PMID  11978763.
  25. ^ Abd El-Aziz, M. M.; Barragan, I.; O'Driscoll, C. A.; Goodstadt, L.; Prigmore, E.; Borrego, S.; Mena, M.; Pieras, J. I.; El-Ashry, M. F.; Safieh, L. A.; Shah, A.; Cheetham, M. E.; Carter, N. P.; Chakarova, C.; Ponting, C. P.; Bhattacharya, S. S.; Antinolo, G. (2008). "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa". Nature Genetics. 40 (11): 1285–1287. doi: 10.1038/ng.241. PMC  2719291. PMID  18836446.
  26. ^ Dickens, N. J.; Beatson, S.; Ponting, C. P. (2002). "Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins". Current Biology. 12 (6): R197–R199. doi: 10.1016/S0960-9822(02)00748-0. PMID  11909544. S2CID  15872294.
  27. ^ Crow, Y. J.; Leitch, A.; Hayward, B. E.; Garner, A.; Parmar, R.; Griffith, E.; Ali, M.; Semple, C.; Aicardi, J.; Babul-Hirji, R.; Baumann, C.; Baxter, P.; Bertini, E.; Chandler, K. E.; Chitayat, D.; Cau, D.; Déry, C.; Fazzi, E.; Goizet, C.; King, M. D.; Klepper, J.; Lacombe, D.; Lanzi, G.; Lyall, H.; Martínez-Frías, M. A. L.; Mathieu, M. L.; McKeown, C.; Monier, A.; Oade, Y.; Quarrell, O. W. (2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature Genetics. 38 (8): 910–916. doi: 10.1038/ng1842. PMID  16845400. S2CID  8076225.
  28. ^ Chris Ponting Research Group MRC Human Genetics Research Unit. July 2021.
Retrieved from " https://en.wikipedia.org/?title=Chris_Ponting&oldid=1203206745"

Videos

Youtube | Vimeo | Bing

Websites

Google | Yahoo | Bing

Encyclopedia

Google | Yahoo | Bing

Facebook




Top Of Page

Home • Search • Translate

© CSE