The China Kadoorie Biobank is acquiring genomic data on half a million Chinese participants. In 2022 Genome-wide genotyping had been conducted for more than 100,000 participants using custom-designed Axiom® arrays. [1]
It collected questionnaire and physical data and blood samples on 510,000 men and women aged between 30 and 79 from 10 regions in China between 2004-2008 with the aim of investigating chronic diseases (e.g. heart attack, stroke, diabetes, and cancer). Participants have been linked to mortality registers and nationwide health systems and a sub-group of 25,000 are retested every few years. It is a joint venture by the University of Oxford’s Clinical Trial Service Unit & Epidemiological Studies Unit and the Chinese Academy of Medical Sciences. [2]
Research based on the biobank published by the American Thoracic Society in 2018 found that respiratory disease hospitalization or death were 36% higher among people who used wood or coal for cooking compared to those who used electricity or gas. [3]
A study published in Heart based on the biobank found that people who ate an egg a day had a lower incidence of cardiovascular disease overall than those who ate no eggs. They had a 25% lower incidence of hemorrhagic stroke, and a 12% reduction in risk of ischemic heart disease. [4]
A study published in 2022 examined the relative risk of mortality associated with five individual and combined lifestyle factors - never smoking or quitting not for illness, no excessive alcohol use, being physically active, healthy eating habits, and healthy body shape - and established that they could be associated with substantial gains in life expectancy in the Chinese population. [5]
References
- ^ Walters, Robin G.; Millwood, Iona Y.; Lin, Kuang; Valle, Dan Schmidt; McDonnell, Pandora; Hacker, Alex; Avery, Daniel; Cai, Na; Kretzschmar, Warren W.; Ansari, M Azim; Lyons, Paul A.; Collins, Rory; Donnelly, Peter; Hill, Michael; Peto, Richard; Shen, Hongbing; Jin, Xin; Nie, Chao; Xu, Xun; Guo, Yu; Yu, Canqing; Lv, Jun; Clarke, Robert J.; Li, Liming; Chen, Zhengming (3 May 2022). "Genotyping and population structure of the China Kadoorie Biobank". Medrxiv. doi: 10.1101/2022.05.02.22274487. Retrieved 11 November 2022.
- ^ (2014) China Kadoorie Biobank University of Oxford, Retrieved 28 January 2015
- ^ "Cooking with wood or coal is linked to increased risk of respiratory illness and death". Science Daily. 21 September 2018. Retrieved 1 October 2018.
- ^ "Recent studies show the benefits of eating eggs". Daily Herald. 25 August 2018. Retrieved 1 October 2018.
- ^ "Healthy lifestyle and life expectancy at age 30 years in the Chinese population: an observational study". Lancet Public Health. 1 August 2022. Retrieved 11 November 2022.
The China Kadoorie Biobank is acquiring genomic data on half a million Chinese participants. In 2022 Genome-wide genotyping had been conducted for more than 100,000 participants using custom-designed Axiom® arrays. [1]
It collected questionnaire and physical data and blood samples on 510,000 men and women aged between 30 and 79 from 10 regions in China between 2004-2008 with the aim of investigating chronic diseases (e.g. heart attack, stroke, diabetes, and cancer). Participants have been linked to mortality registers and nationwide health systems and a sub-group of 25,000 are retested every few years. It is a joint venture by the University of Oxford’s Clinical Trial Service Unit & Epidemiological Studies Unit and the Chinese Academy of Medical Sciences. [2]
Research based on the biobank published by the American Thoracic Society in 2018 found that respiratory disease hospitalization or death were 36% higher among people who used wood or coal for cooking compared to those who used electricity or gas. [3]
A study published in Heart based on the biobank found that people who ate an egg a day had a lower incidence of cardiovascular disease overall than those who ate no eggs. They had a 25% lower incidence of hemorrhagic stroke, and a 12% reduction in risk of ischemic heart disease. [4]
A study published in 2022 examined the relative risk of mortality associated with five individual and combined lifestyle factors - never smoking or quitting not for illness, no excessive alcohol use, being physically active, healthy eating habits, and healthy body shape - and established that they could be associated with substantial gains in life expectancy in the Chinese population. [5]
References
- ^ Walters, Robin G.; Millwood, Iona Y.; Lin, Kuang; Valle, Dan Schmidt; McDonnell, Pandora; Hacker, Alex; Avery, Daniel; Cai, Na; Kretzschmar, Warren W.; Ansari, M Azim; Lyons, Paul A.; Collins, Rory; Donnelly, Peter; Hill, Michael; Peto, Richard; Shen, Hongbing; Jin, Xin; Nie, Chao; Xu, Xun; Guo, Yu; Yu, Canqing; Lv, Jun; Clarke, Robert J.; Li, Liming; Chen, Zhengming (3 May 2022). "Genotyping and population structure of the China Kadoorie Biobank". Medrxiv. doi: 10.1101/2022.05.02.22274487. Retrieved 11 November 2022.
- ^ (2014) China Kadoorie Biobank University of Oxford, Retrieved 28 January 2015
- ^ "Cooking with wood or coal is linked to increased risk of respiratory illness and death". Science Daily. 21 September 2018. Retrieved 1 October 2018.
- ^ "Recent studies show the benefits of eating eggs". Daily Herald. 25 August 2018. Retrieved 1 October 2018.
- ^ "Healthy lifestyle and life expectancy at age 30 years in the Chinese population: an observational study". Lancet Public Health. 1 August 2022. Retrieved 11 November 2022.