Charantin is a chemical substance obtained from the Asian bitter melon (Momordica charantia), reputed to be responsible for the hypoglycaemic properties of those plants. It was identified by Lolitkar and Rao in 1960. [1] [2] It was also found in the similar African species M. foetida, by A. Olaniyi in 1975, under the name foetidin. [3]
Charantin is actually a 1:1 mixture of two
steroidal
saponins,
β-sitosteryl
glucoside (C
35H
60O
6) and
5,22-stigmasteryl glucoside (C
35H
58O
6).
[3] It is a whitish crystalline substance,
neutral and tasteless, melting at 266–268 °C. It is
sparingly soluble in water
[1] or other highly
polar solvents, as well as in
apolar solvents like
hexane, but is soluble in
ether,
ethanol and
methanol, and can be efficiently extracted from the plant by pressurized
ethanol or
acetone at 100 °C.
[4]
The name charantin has also been used by A. Parkash and other for a different compound, a peptide with molecular mass 9.7 kDa, also isolated from bitter melon seeds. [5]
Charantin is a chemical substance obtained from the Asian bitter melon (Momordica charantia), reputed to be responsible for the hypoglycaemic properties of those plants. It was identified by Lolitkar and Rao in 1960. [1] [2] It was also found in the similar African species M. foetida, by A. Olaniyi in 1975, under the name foetidin. [3]
Charantin is actually a 1:1 mixture of two
steroidal
saponins,
β-sitosteryl
glucoside (C
35H
60O
6) and
5,22-stigmasteryl glucoside (C
35H
58O
6).
[3] It is a whitish crystalline substance,
neutral and tasteless, melting at 266–268 °C. It is
sparingly soluble in water
[1] or other highly
polar solvents, as well as in
apolar solvents like
hexane, but is soluble in
ether,
ethanol and
methanol, and can be efficiently extracted from the plant by pressurized
ethanol or
acetone at 100 °C.
[4]
The name charantin has also been used by A. Parkash and other for a different compound, a peptide with molecular mass 9.7 kDa, also isolated from bitter melon seeds. [5]