Clinical data | |
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Other names | 4548-G05 |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C30H26O10 |
Molar mass | 546.528 g·mol−1 |
3D model ( JSmol) | |
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Chaetochromin, also known as 4548-G05, is an orally active, small-molecule, selective agonist of the insulin receptor. [1] It has potent and long-lasting antidiabetic activity in vivo in mice. [1] The drug may represent a novel potential therapeutic agent for the treatment of diabetes which is more convenient and tolerable to administer than injected insulin. [1] It was discovered in 1981 in Chaetomium gracile fungi, [2] and its interaction with the insulin receptor was identified in 2014. [1]
Chaetochromin A and B are stereoisomers of this structure, while chaetochromin C and D are related but different compounds. [3] It is not known whether the insulin mimetic effect was found in chaetochromin A or B, or in a mixture. [1]
Clinical data | |
---|---|
Other names | 4548-G05 |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C30H26O10 |
Molar mass | 546.528 g·mol−1 |
3D model ( JSmol) | |
| |
|
Chaetochromin, also known as 4548-G05, is an orally active, small-molecule, selective agonist of the insulin receptor. [1] It has potent and long-lasting antidiabetic activity in vivo in mice. [1] The drug may represent a novel potential therapeutic agent for the treatment of diabetes which is more convenient and tolerable to administer than injected insulin. [1] It was discovered in 1981 in Chaetomium gracile fungi, [2] and its interaction with the insulin receptor was identified in 2014. [1]
Chaetochromin A and B are stereoisomers of this structure, while chaetochromin C and D are related but different compounds. [3] It is not known whether the insulin mimetic effect was found in chaetochromin A or B, or in a mixture. [1]