Centrilobular necrosis | |
---|---|
Other names | Central lobular necrosis, CN |
Histopathology of shock liver (intermediate magnification), showing centrilobular necrosis but viable periportal hepatocytes. |
Centrilobular necrosis (CN) is a nonspecific histopathological observation brought on by hepatotoxins like acetaminophen (paracetamol), [1] thioacetamide, tetrachloride, [2] cardiac hepatopathy due to acute right sided cardiac failure, and congestive hepatic injury in veno‐occlusive disease, [3] or hypoxic injury due to ischemia. [2] Centrilobular necrosis can also be found in those with autoimmune hepatitis. [4] Centrilobular necrosis is characterized by necrotic hepatocytes completely encircling the central vein. [5]
After a single or brief exposure to a toxicant, hepatocytes that have suffered centrilobular necrosis typically heal quickly; the liver can regain its normal appearance under a microscope in about a week. Nevertheless, fibrosis, which may be slight, occurs in the previously necrotic zone surrounding the central vein when regeneration replaces the necrotic hepatocytes if sinusoidal cells and the normal scaffolding are destroyed. [5]
Centrilobular necrosis | |
---|---|
Other names | Central lobular necrosis, CN |
Histopathology of shock liver (intermediate magnification), showing centrilobular necrosis but viable periportal hepatocytes. |
Centrilobular necrosis (CN) is a nonspecific histopathological observation brought on by hepatotoxins like acetaminophen (paracetamol), [1] thioacetamide, tetrachloride, [2] cardiac hepatopathy due to acute right sided cardiac failure, and congestive hepatic injury in veno‐occlusive disease, [3] or hypoxic injury due to ischemia. [2] Centrilobular necrosis can also be found in those with autoimmune hepatitis. [4] Centrilobular necrosis is characterized by necrotic hepatocytes completely encircling the central vein. [5]
After a single or brief exposure to a toxicant, hepatocytes that have suffered centrilobular necrosis typically heal quickly; the liver can regain its normal appearance under a microscope in about a week. Nevertheless, fibrosis, which may be slight, occurs in the previously necrotic zone surrounding the central vein when regeneration replaces the necrotic hepatocytes if sinusoidal cells and the normal scaffolding are destroyed. [5]