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Clinical data | |
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Trade names | Canocenta, Privaprol |
Other names | Trazisoquine; L-12717; DL-717-IT |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.060.340 |
Chemical and physical data | |
Formula | C16H10ClN3 |
Molar mass | 279.73 g·mol−1 |
3D model ( JSmol) | |
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Lotrifen ( INN ), also known as trazisoquine and sold under the brand names Canocenta and Privaprol, is an abortifacient which is used in veterinary medicine. [1] [2] It was described in 1978. [1]
Reaction of the acyl hydrazide (1) and the carboximidate (2) gives compound (3). Heating this in the presence of sodium hydride cyclises this intermediate, forming the 1,2,4-triazole ring system of the drug. Oxidation of (4) with N-bromoacetamide yields lotrifen. [3] [4]
![]() | |
Clinical data | |
---|---|
Trade names | Canocenta, Privaprol |
Other names | Trazisoquine; L-12717; DL-717-IT |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.060.340 |
Chemical and physical data | |
Formula | C16H10ClN3 |
Molar mass | 279.73 g·mol−1 |
3D model ( JSmol) | |
| |
|
Lotrifen ( INN ), also known as trazisoquine and sold under the brand names Canocenta and Privaprol, is an abortifacient which is used in veterinary medicine. [1] [2] It was described in 1978. [1]
Reaction of the acyl hydrazide (1) and the carboximidate (2) gives compound (3). Heating this in the presence of sodium hydride cyclises this intermediate, forming the 1,2,4-triazole ring system of the drug. Oxidation of (4) with N-bromoacetamide yields lotrifen. [3] [4]