Caetano Maria Pacheco Pais dos Reis e Sousa (born 1968) ^[3] FRS FMedSci is a senior group leader at the Francis Crick Institute ^{[2] [4] [5] [6]} and a professor of Immunology at Imperial College London. ^[7]

Reis e Sousa was educated at Atlantic College in Wales, ^[6] Imperial College London (BSc) and the University of Oxford where he was awarded a Doctor of Philosophy degree in 1992 for research on dendritic cells, and the phagocytosis of antigens by Langerhans cells supervised by Jonathan Austyn. ^[8]

After working as a postdoctoral researcher at the National Institute of Allergy and Infectious Diseases (NIAID) in the United States, with Ronald Germain, he joined the Imperial Cancer Research Fund (ICRF) in 1998. ^[9] He headed the Immunobiology Laboratory which became part of the Francis Crick Institute in 2015. ^[9] He is also a professor of Immunology at Imperial College London ^{[10] [7]} and honorary professor at University College London (UCL) and King's College London. ^[9]

Caetano's research centres on the mechanisms involved in sensing infection, cancer and tissue injury. ^[9] He has helped to define the cells and pathways involved in innate immune detection of RNA viruses, fungi and dead cells. ^{[9] [11] [12] [13]}

Reis e Sousa was elected a Fellow of the Royal Society (FRS) in 2019, and is also a Fellow of the Academy of Medical Sciences (FMedSci), a member of the European Molecular Biology Organization (EMBO) ^[1] and was made an Officer of the Order of Sant'Iago da Espada by the Government of Portugal in 2009. ^[9] He was awarded the Louis-Jeantet Prize for Medicine in 2017. ^[3]