CUGBP, Elav-like family member 2, also known as Etr-3 is a
protein that in humans is encoded by the CELF2gene.[5][6][7]
Members of the CELF/BRUNOL protein family are
RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA
alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different
isoforms.[7]
Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401.
doi:
10.1006/geno.2001.6558.
PMID11414768.
Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42.
doi:
10.1007/s00109-002-0331-9.
PMID12110949.
S2CID24098272.
CUGBP, Elav-like family member 2, also known as Etr-3 is a
protein that in humans is encoded by the CELF2gene.[5][6][7]
Members of the CELF/BRUNOL protein family are
RNA-binding proteins and contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA
alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different
isoforms.[7]
Li D, Bachinski LL, Roberts R (2001). "Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia". Genomics. 74 (3): 396–401.
doi:
10.1006/geno.2001.6558.
PMID11414768.
Lichtner P, Attié-Bitach T, Schuffenhauer S, et al. (2003). "Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p". J. Mol. Med. 80 (7): 431–42.
doi:
10.1007/s00109-002-0331-9.
PMID12110949.
S2CID24098272.