CTP synthase 2 is an
enzyme that in humans is encoded by the CTPS2gene.[5][6]
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of
glutamine to
glutamate.
This protein is the rate-limiting enzyme in the synthesis of
cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of
RNA and DNA.
Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.
Thus, this protein is an attractive target for selective
chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]
CTP synthase 2 is an
enzyme that in humans is encoded by the CTPS2gene.[5][6]
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of
glutamine to
glutamate.
This protein is the rate-limiting enzyme in the synthesis of
cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of
RNA and DNA.
Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.
Thus, this protein is an attractive target for selective
chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]