From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Copine-8 is a
protein that in humans is encoded by the CPNE8
gene .
[5]
[6]
Calcium -dependent membrane-binding proteins may regulate molecular events at the interface of the
cell membrane and
cytoplasm . This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the
C-terminus .
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000139117 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000052560 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003).
"Cloning, molecular characterization, and expression analysis of Copine 8" . Biochem Biophys Res Commun . 303 (3): 842–847.
doi :
10.1016/S0006-291X(03)00445-5 .
PMID
12670487 .
^
a
b
"Entrez Gene: CPNE8 copine VIII" .
Further reading
Creutz CE, Tomsig JL, Snyder SL, et al. (1998).
"The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans" . J. Biol. Chem . 273 (3): 1393–1402.
doi :
10.1074/jbc.273.3.1393 .
PMID
9430674 .
Hartley JL, Temple GF, Brasch MA (2001).
"DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–1795.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Tomsig JL, Creutz CE (2001). "Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein". Biochemistry . 39 (51): 16163–16175.
doi :
10.1021/bi0019949 .
PMID
11123945 .
Wiemann S, Weil B, Wellenreuther R, et al. (2001).
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–435.
doi :
10.1101/gr.GR1547R .
PMC
311072 .
PMID
11230166 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ramsey H, Zhang DE, Richkind K, et al. (2003).
"Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation" . Leukemia . 17 (8): 1665–1666.
doi :
10.1038/sj.leu.2403048 .
PMID
12886257 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–2144.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–D418.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
External links