This gene is a member of the
carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on
chromosome 7. Carboxypeptidases are
zinc-containing
exopeptidases that catalyze the release of carboxy-terminal
amino acids, and are synthesized as
zymogens that are activated by
proteolytic cleavage. This gene could be involved in the
histone hyperacetylation pathway. It is
imprinted and may be a strong candidate gene for
prostate cancer aggressiveness.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI (Jul 1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells". Cancer Res. 59 (12): 2981–8.
PMID10383164.
^Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5.
doi:
10.1006/geno.2000.6206.
PMID10860668.
This gene is a member of the
carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on
chromosome 7. Carboxypeptidases are
zinc-containing
exopeptidases that catalyze the release of carboxy-terminal
amino acids, and are synthesized as
zymogens that are activated by
proteolytic cleavage. This gene could be involved in the
histone hyperacetylation pathway. It is
imprinted and may be a strong candidate gene for
prostate cancer aggressiveness.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI (Jul 1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells". Cancer Res. 59 (12): 2981–8.
PMID10383164.
^Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5.
doi:
10.1006/geno.2000.6206.
PMID10860668.