Cytochrome c oxidase subunit Vb | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() Structure of the 13-subunit oxidized cytochrome c oxidase.
[1] | |||||||||||
Identifiers | |||||||||||
Symbol | COX5B | ||||||||||
Pfam | PF01215 | ||||||||||
InterPro | IPR002124 | ||||||||||
PROSITE | PDOC00663 | ||||||||||
SCOP2 | 1occ / SCOPe / SUPFAM | ||||||||||
OPM superfamily | 4 | ||||||||||
OPM protein | 1v55 | ||||||||||
CDD | cd00924 | ||||||||||
|
Cytochrome c oxidase subunit 5B, mitochondrial is an enzyme in humans that is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain. [2] In humans, cytochrome c oxidase subunit 5B is encoded by the COX5B gene.
The enzyme weighs 14 kDa and is composed of 129 amino acids. [3] [4] The protein is a subunit of Complex IV, which consists of 13 mitochondrial- and nuclear-encoded subunits. [2] The sequence of subunit Vb is well conserved and includes three conserved cysteines that coordinate the zinc ion. [5] [6] Two of these cysteines are clustered in the C-terminal section of the subunit.
COX5B | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | COX5B, cytochrome c oxidase subunit Vb, COXVB, cytochrome c oxidase subunit 5B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 123866; MGI: 88475; HomoloGene: 37538; GeneCards: COX5B; OMA: COX5B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
The COX5B gene, located on the q arm of chromosome 2 in position 11.2, is made up of 4 exons and is 2,137 base pairs in length. [2]
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane to drive ATP synthesis via protonmotive force. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. [2]
Summary reaction:
COX5A and COX5B are involved in the regulation of cancer cell metabolism by Bcl-2. [12]
The Trans-activator of transcription protein (Tat) of human immunodeficiency virus (HIV) inhibits cytochrome c oxidase (COX) activity in permeabilized mitochondria isolated from both mouse and human liver, heart, and brain samples. [13]
COX5B has been shown to interact with Androgen receptor. [14]
{{
cite book}}
: CS1 maint: multiple names: authors list (
link)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Cytochrome c oxidase subunit Vb | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() Structure of the 13-subunit oxidized cytochrome c oxidase.
[1] | |||||||||||
Identifiers | |||||||||||
Symbol | COX5B | ||||||||||
Pfam | PF01215 | ||||||||||
InterPro | IPR002124 | ||||||||||
PROSITE | PDOC00663 | ||||||||||
SCOP2 | 1occ / SCOPe / SUPFAM | ||||||||||
OPM superfamily | 4 | ||||||||||
OPM protein | 1v55 | ||||||||||
CDD | cd00924 | ||||||||||
|
Cytochrome c oxidase subunit 5B, mitochondrial is an enzyme in humans that is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain. [2] In humans, cytochrome c oxidase subunit 5B is encoded by the COX5B gene.
The enzyme weighs 14 kDa and is composed of 129 amino acids. [3] [4] The protein is a subunit of Complex IV, which consists of 13 mitochondrial- and nuclear-encoded subunits. [2] The sequence of subunit Vb is well conserved and includes three conserved cysteines that coordinate the zinc ion. [5] [6] Two of these cysteines are clustered in the C-terminal section of the subunit.
COX5B | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | COX5B, cytochrome c oxidase subunit Vb, COXVB, cytochrome c oxidase subunit 5B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 123866; MGI: 88475; HomoloGene: 37538; GeneCards: COX5B; OMA: COX5B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
The COX5B gene, located on the q arm of chromosome 2 in position 11.2, is made up of 4 exons and is 2,137 base pairs in length. [2]
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane to drive ATP synthesis via protonmotive force. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. [2]
Summary reaction:
COX5A and COX5B are involved in the regulation of cancer cell metabolism by Bcl-2. [12]
The Trans-activator of transcription protein (Tat) of human immunodeficiency virus (HIV) inhibits cytochrome c oxidase (COX) activity in permeabilized mitochondria isolated from both mouse and human liver, heart, and brain samples. [13]
COX5B has been shown to interact with Androgen receptor. [14]
{{
cite book}}
: CS1 maint: multiple names: authors list (
link)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.