Coronin, actin binding protein, 1B also known as CORO1B is a
protein which in humans is encoded by the CORO1Bgene.[1] Members of the
coronin family, such as CORO1B, are
WD repeat-containing
actin-binding proteins that regulate
cell motility.[2]
Function
A mammalian
coronin enriches at the leading edge of migrating cells.[3] Studies related to this protein are as follows:
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.[4]
F-actin binding is essential for coronin 1B function in vivo.[5]
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.[6]
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.[2]
In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.[7]
Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.[8]
References
^Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87.
doi:
10.1089/dna.1998.17.779.
PMID9778037.
Coronin, actin binding protein, 1B also known as CORO1B is a
protein which in humans is encoded by the CORO1Bgene.[1] Members of the
coronin family, such as CORO1B, are
WD repeat-containing
actin-binding proteins that regulate
cell motility.[2]
Function
A mammalian
coronin enriches at the leading edge of migrating cells.[3] Studies related to this protein are as follows:
Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.[4]
F-actin binding is essential for coronin 1B function in vivo.[5]
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.[6]
Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.[2]
In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.[7]
Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.[8]
References
^Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (September 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87.
doi:
10.1089/dna.1998.17.779.
PMID9778037.