CORIN
Identifiers
Aliases	CORIN, ATC2, CRN, Lrp4, PEE5, TMPRSS10, corin, serine peptidase
External IDs	OMIM: 605236; MGI: 1349451; HomoloGene: 4804; GeneCards: CORIN; OMA: CORIN - orthologs
Gene location ( Human) Chr. Chromosome 4 (human) [1] Band 4p12 Start 47,593,999 bp [1] End 47,838,106 bp [1]
Gene location ( Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C3.2 Start 72,457,368 bp [2] End 72,661,816 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle human penis stromal cell of endometrium urethra nipple myometrium seminal vesicula gallbladder vagina anterior pituitary Top expressed in myocardium of ventricle atrium right ventricle atrioventricular valve belly cord interventricular septum hair follicle endocardial cushion spermatocyte semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity hydrolase activity serine-type peptidase activity serine-type endopeptidase activity Cellular component integral component of membrane cell surface integral component of plasma membrane extracellular region membrane plasma membrane actin cytoskeleton nuclear body Biological process regulation of cardiac conduction regulation of renal sodium excretion proteolysis regulation of blood pressure regulation of systemic arterial blood pressure by atrial natriuretic peptide peptide hormone processing female pregnancy Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10699 53419 Ensembl ENSG00000145244 ENSMUSG00000005220 UniProt Q9Y5Q5 Q9Z319 RefSeq (mRNA) NM_006587 NM_001278585 NM_001278586 NM_001122756 NM_016869 RefSeq (protein) NP_001265514 NP_001265515 NP_006578 NP_001116228 NP_058565 Location (UCSC) Chr 4: 47.59 – 47.84 Mb Chr 5: 72.46 – 72.66 Mb PubMed search [3] [4]
Wikidata
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Corin, also called atrial natriuretic peptide-converting enzyme, is a protein that in humans is encoded by the CORIN gene. ^{[5] [6]}

Protein

Human corin, a polypeptide of 1042 amino acids, consists of an N-terminal cytoplasmic domain, a transmembrane domain and an extracellular region with two frizzled-like domains, eight LDL receptor-like domains, a scavenger receptor-like domain and a C-terminal trypsin-like serine protease domain. ^{[5] [7]} Corin is synthesized as a zymogen that is activated by PCSK6. ^[8]

Corin exhibits a trypsin-like catalytic activity favoring basic residues at the P1 position. ^[9]

Human corin contains 19 N-glycosylation sites. ^[5] N-glycans promote corin expression on the cell surface and protect corin from metalloproteinase-mediated shedding. ^{[10] [11] [12]}

Function

Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt-water balance and blood pressure. ^[13] In mice, corin deficiency prevents pro-ANP processing and causes salt-sensitive hypertension. ^{[14] [15]}

Corin may also function as a pro-brain-type natriuretic peptide convertase. ^{[13] [16] [17]}

Corin-mediated ANP production in the pregnant uterus promotes spiral artery remodeling and trophoblast invasion. ^[18] CORIN mutations have been reported in patients with preeclampsia. ^{[18] [19]}

In mice, corin functions in the dermal papilla to regulate coat color in an Agouti-dependent pathway. ^[20]

Variants and mutations

Variants encoded by alternative exons were reported in human and mouse corin. ^[21] A variant allele (T555I/Q568P) was found in African Americans with hypertension and cardiac hypertrophy. ^{[22] [23]} The amino acid substitutions impaired corin activity. ^{[24] [25]} An insertion variant in exon 1 alters the cytoplasmic tail. ^[26] This variant appeared more frequently in hypertensive patients. CORIN mutations were found in patients with hypertension. ^{[27] [18] [19] [28]}

References

Further reading

External links

• Human CORIN genome location and CORIN gene details page in the UCSC Genome Browser.