COP9 signalosome complex subunit 6 is a
protein that in humans is encoded by the COPS6gene.[5]
Function
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.[6]
Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33.
doi:
10.1038/ncb1203-1029.
PMID14647295.
S2CID37458780.
Elder RT, Yu M, Chen M, Edelson S, Zhao Y (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint". Virus Res. 68 (2): 161–73.
doi:
10.1016/S0168-1702(00)00167-2.
PMID10958988.
Ramanathan MP, Ayyavoo V, Weiner DB (2001). "Choice of expression vector alters the localization of a human cellular protein". DNA Cell Biol. 20 (2): 101–5.
doi:
10.1089/104454901750070300.
PMID11244567.
COP9 signalosome complex subunit 6 is a
protein that in humans is encoded by the COPS6gene.[5]
Function
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.[6]
Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33.
doi:
10.1038/ncb1203-1029.
PMID14647295.
S2CID37458780.
Elder RT, Yu M, Chen M, Edelson S, Zhao Y (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint". Virus Res. 68 (2): 161–73.
doi:
10.1016/S0168-1702(00)00167-2.
PMID10958988.
Ramanathan MP, Ayyavoo V, Weiner DB (2001). "Choice of expression vector alters the localization of a human cellular protein". DNA Cell Biol. 20 (2): 101–5.
doi:
10.1089/104454901750070300.
PMID11244567.