Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. [1] Since it was first identified in 2001, [2] other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. [1]
The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. [3] They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines. [3]
The COMPASS complex is an example of a trithorax-group protein. [1] The MLL1/SET domain associated with the COMPASS complex have crystal structure. [3] The gene Cps50 coordinates the construction of COMPASS. [4]
Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. [1] Since it was first identified in 2001, [2] other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. [1]
The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. [3] They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines. [3]
The COMPASS complex is an example of a trithorax-group protein. [1] The MLL1/SET domain associated with the COMPASS complex have crystal structure. [3] The gene Cps50 coordinates the construction of COMPASS. [4]