From Wikipedia, the free encyclopedia

Introduction

Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. [1] Since it was first identified in 2001, [2] other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. [1]

The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. [3] They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines. [3]

The COMPASS complex is an example of a trithorax-group protein. [1] The MLL1/SET domain associated with the COMPASS complex have crystal structure. [3] The gene Cps50 coordinates the construction of COMPASS. [4]

References

  1. ^ a b c Shilatifard, Ali (December 10, 2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual Review of Biochemistry. 81 (1): 65–95. doi: 10.1146/annurev-biochem-051710-134100. PMC  4010150. PMID  22663077.
  2. ^ Miller, Trissa; Krogan, Nevan J.; Dover, Jim; Erdjument-Bromage, H.; Tempst, Paul; Johnston, Mark; Greenblatt, Jack F.; Shilatifard, Ali (November 6, 2001). "COMPASS: A complex of proteins associated with a trithorax-related SET domain protein". Proceedings of the National Academy of Sciences. 98 (23): 12902–12907. Bibcode: 2001PNAS...9812902M. doi: 10.1073/pnas.231473398. PMC  60797. PMID  11687631.
  3. ^ a b c Takahashi, Yoh-hei; Westfield, Gerwin H.; Oleskie, Austin N.; Trievel, Raymond C.; Shilatifard, Ali; Skiniotis, Georgios (2011-12-20). "Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human". Proceedings of the National Academy of Sciences. 108 (51): 20526–20531. Bibcode: 2011PNAS..10820526T. doi: 10.1073/pnas.1109360108. ISSN  0027-8424. PMC  3251153. PMID  22158900.
  4. ^ Qu, Qianhui; Takahashi, Yoh-hei; Yang, Yidai; Hu, Hongli; Zhang, Yan; Brunzelle, Joseph S.; Couture, Jean-Francois; Shilatifard, Ali; Skiniotis, Georgios (2018-08-23). "Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex". Cell. 174 (5): 1117–1126.e12. doi: 10.1016/j.cell.2018.07.020. ISSN  0092-8674. PMC  6108936. PMID  30100186.


From Wikipedia, the free encyclopedia

Introduction

Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. [1] Since it was first identified in 2001, [2] other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans. [1]

The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans. [3] They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines. [3]

The COMPASS complex is an example of a trithorax-group protein. [1] The MLL1/SET domain associated with the COMPASS complex have crystal structure. [3] The gene Cps50 coordinates the construction of COMPASS. [4]

References

  1. ^ a b c Shilatifard, Ali (December 10, 2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual Review of Biochemistry. 81 (1): 65–95. doi: 10.1146/annurev-biochem-051710-134100. PMC  4010150. PMID  22663077.
  2. ^ Miller, Trissa; Krogan, Nevan J.; Dover, Jim; Erdjument-Bromage, H.; Tempst, Paul; Johnston, Mark; Greenblatt, Jack F.; Shilatifard, Ali (November 6, 2001). "COMPASS: A complex of proteins associated with a trithorax-related SET domain protein". Proceedings of the National Academy of Sciences. 98 (23): 12902–12907. Bibcode: 2001PNAS...9812902M. doi: 10.1073/pnas.231473398. PMC  60797. PMID  11687631.
  3. ^ a b c Takahashi, Yoh-hei; Westfield, Gerwin H.; Oleskie, Austin N.; Trievel, Raymond C.; Shilatifard, Ali; Skiniotis, Georgios (2011-12-20). "Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human". Proceedings of the National Academy of Sciences. 108 (51): 20526–20531. Bibcode: 2011PNAS..10820526T. doi: 10.1073/pnas.1109360108. ISSN  0027-8424. PMC  3251153. PMID  22158900.
  4. ^ Qu, Qianhui; Takahashi, Yoh-hei; Yang, Yidai; Hu, Hongli; Zhang, Yan; Brunzelle, Joseph S.; Couture, Jean-Francois; Shilatifard, Ali; Skiniotis, Georgios (2018-08-23). "Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex". Cell. 174 (5): 1117–1126.e12. doi: 10.1016/j.cell.2018.07.020. ISSN  0092-8674. PMC  6108936. PMID  30100186.



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