C-type lectin domain family 2 member D is a
protein that in humans is encoded by the CLEC2Dgene.[3]
This gene encodes a member of the
natural killer cell receptor C-type
lectin family. The encoded protein inhibits
osteoclast formation and contains a
transmembrane domain near the
N-terminus as well as the C-type lectin-like
extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional
ligand for the human NKR-P1A receptor, encoded by the
KLRB1 gene.
In mice, there are many
orthologs of the CLEC2D gene, and the presumed
homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.
Boles KS, Barten R, Kumaresan PR, et al. (1999). "Cloning of a new lectin-like receptor expressed on human NK cells". Immunogenetics. 50 (1–2): 1–7.
doi:
10.1007/s002510050679.
PMID10541800.
S2CID30994521.
C-type lectin domain family 2 member D is a
protein that in humans is encoded by the CLEC2Dgene.[3]
This gene encodes a member of the
natural killer cell receptor C-type
lectin family. The encoded protein inhibits
osteoclast formation and contains a
transmembrane domain near the
N-terminus as well as the C-type lectin-like
extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional
ligand for the human NKR-P1A receptor, encoded by the
KLRB1 gene.
In mice, there are many
orthologs of the CLEC2D gene, and the presumed
homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.
Boles KS, Barten R, Kumaresan PR, et al. (1999). "Cloning of a new lectin-like receptor expressed on human NK cells". Immunogenetics. 50 (1–2): 1–7.
doi:
10.1007/s002510050679.
PMID10541800.
S2CID30994521.