Claudin-2 is a
protein that in humans is encoded by the CLDN2gene.[5][6] It belongs to the group of
claudins.
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][6]
Function
Claudin-2 is expressed in
cation-leaky
epithelia such as that of the
kidneyproximal tubule.[7] Mice that are
deficient in claudin-2 have reduced
reabsorption of
Na+ in the proximal tubule, consistent with a role in
paracellular transport.
Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[8]
Furthermore, claudin-2 has been shown to form paracellular channels for water.[9]
^Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76.
doi:
10.1242/jcs.00165.
PMID12432083.
S2CID30696935.
^Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Gunzel D, Fromm M (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921.
doi:
10.1242/jcs.060665.
PMID20460438.
S2CID19797060.
Escaffit F, Boudreau F, Beaulieu JF (2005). "Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells". J. Cell. Physiol. 203 (1): 15–26.
doi:
10.1002/jcp.20189.
PMID15389642.
S2CID39780124.
Claudin-2 is a
protein that in humans is encoded by the CLDN2gene.[5][6] It belongs to the group of
claudins.
Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][6]
Function
Claudin-2 is expressed in
cation-leaky
epithelia such as that of the
kidneyproximal tubule.[7] Mice that are
deficient in claudin-2 have reduced
reabsorption of
Na+ in the proximal tubule, consistent with a role in
paracellular transport.
Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[8]
Furthermore, claudin-2 has been shown to form paracellular channels for water.[9]
^Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76.
doi:
10.1242/jcs.00165.
PMID12432083.
S2CID30696935.
^Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Gunzel D, Fromm M (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921.
doi:
10.1242/jcs.060665.
PMID20460438.
S2CID19797060.
Escaffit F, Boudreau F, Beaulieu JF (2005). "Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells". J. Cell. Physiol. 203 (1): 15–26.
doi:
10.1002/jcp.20189.
PMID15389642.
S2CID39780124.