From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Claudin-18 is a
protein that in humans is encoded by the CLDN18
gene.
[5] It belongs to the group of
claudins.
CLDN18 belongs to the large
claudin family of proteins, which form
tight junction strands in epithelial cells .
[6] [supplied by OMIM]
[5]
Clinical significance
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
[7]
Experimental antibody
IMAB362 targets Claudin 18.2 to help treat gastric cancers.
[7]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000066405 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032473 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
a
b
"Entrez Gene: CLDN18 claudin 18".
-
^ Niimi T, Nagashima K, Ward JM, et al. (2001).
"claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90.
doi:
10.1128/MCB.21.21.7380-7390.2001.
PMC
99911.
PMID
11585919.
- ^
a
b
Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016
External links
Further reading
- Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76.
doi:
10.1023/A:1006995910836.
PMID
10690502.
S2CID
26473781.
- Heiskala M, Peterson PA, Yang Y (2001).
"The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8.
doi:
10.1034/j.1600-0854.2001.020203.x.
PMID
11247307.
S2CID
12132159.
- Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93.
doi:
10.1038/35067088.
PMID
11283726.
S2CID
36524601.
- Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6.
doi:
10.1016/S0955-0674(02)00362-9.
PMID
12231346.
- González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003).
"Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44.
doi:
10.1016/S0079-6107(02)00037-8.
PMID
12475568.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003).
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70.
doi:
10.1101/gr.1293003.
PMC
403697.
PMID
12975309.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54.
doi:
10.1007/s00335-005-0075-2.
PMID
16341674.
S2CID
69278.
- Matsuda Y, Semba S, Ueda J, et al. (2007).
"Gastric and intestinal claudin expression at the invasive front of gastric carcinoma". Cancer Sci. 98 (7): 1014–9.
doi:
10.1111/j.1349-7006.2007.00490.x.
PMC
11159341.
PMID
17459057.
S2CID
28029778.
- Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015).
"A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359.
doi:
10.1021/acs.jproteome.5b00769.
PMC
4777318.
PMID
26680015.