Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a
protein that in humans is encoded by the CLCF1gene.[5]
CLCF1 is a cytokine belonging to the
interleukin-6 (IL6) family. It is a secreted protein, found predominantly in
lymph nodes and
spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called
cardiotrophin-1 and
ciliary neurotrophic factor.
Shi Y, Wang W, Yourey PA, et al. (1999). "Computational EST database analysis identifies a novel member of the neuropoietic cytokine family". Biochem. Biophys. Res. Commun. 262 (1): 132–8.
doi:
10.1006/bbrc.1999.1181.
PMID10448081.
Elson GC, Lelièvre E, Guillet C, et al. (2000). "CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex". Nat. Neurosci. 3 (9): 867–72.
doi:
10.1038/78765.
PMID10966616.
S2CID25766998.
Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a
protein that in humans is encoded by the CLCF1gene.[5]
CLCF1 is a cytokine belonging to the
interleukin-6 (IL6) family. It is a secreted protein, found predominantly in
lymph nodes and
spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called
cardiotrophin-1 and
ciliary neurotrophic factor.
Shi Y, Wang W, Yourey PA, et al. (1999). "Computational EST database analysis identifies a novel member of the neuropoietic cytokine family". Biochem. Biophys. Res. Commun. 262 (1): 132–8.
doi:
10.1006/bbrc.1999.1181.
PMID10448081.
Elson GC, Lelièvre E, Guillet C, et al. (2000). "CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex". Nat. Neurosci. 3 (9): 867–72.
doi:
10.1038/78765.
PMID10966616.
S2CID25766998.