Cytoplasmic linker associated protein 1, also known as CLASP1, is a
protein which in humans is encoded by the CLASP1gene.[5]
Function
CLASP1 belongs to a family of
microtubule-associated proteins involved in attachment of
microtubules to the
cell cortex in animals[6] and plants.[7] CLASPs, such as CLASP1, interact with CLIPs (e.g.,
CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the
kinetochore and throughout the
spindle.[5][8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.[9]
^Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050.
doi:
10.1038/ncb2297.
PMID21822276.
S2CID8869880.
Cytoplasmic linker associated protein 1, also known as CLASP1, is a
protein which in humans is encoded by the CLASP1gene.[5]
Function
CLASP1 belongs to a family of
microtubule-associated proteins involved in attachment of
microtubules to the
cell cortex in animals[6] and plants.[7] CLASPs, such as CLASP1, interact with CLIPs (e.g.,
CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the
kinetochore and throughout the
spindle.[5][8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.[9]
^Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050.
doi:
10.1038/ncb2297.
PMID21822276.
S2CID8869880.