From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinases regulatory subunit 2 is a
protein that in humans is encoded by the CKS2
gene .
[5]
[6]
[7]
CKS2 protein binds to the catalytic subunit of the
cyclin dependent kinases and is essential for their
biological function . The CKS2
mRNA is found to be
expressed in different patterns through the
cell cycle in
HeLa cells , which reflects specialized role for the encoded protein.
[7]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000123975 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000062248 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI (Dec 1990).
"Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe" . Genes Dev . 4 (8): 1332–44.
doi :
10.1101/gad.4.8.1332 .
PMID
2227411 .
^ Demetrick DJ, Zhang H, Beach DH (Sep 1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22". Cytogenet Cell Genet . 73 (3): 250–4.
doi :
10.1159/000134349 .
PMID
8697818 .
^
a
b
"Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2" .
Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control". Science . 262 (5132): 387–95.
Bibcode :
1993Sci...262..387P .
doi :
10.1126/science.8211159 .
PMID
8211159 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Le XF, Lammayot A, Gold D, et al. (2005).
"Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling" . J. Biol. Chem . 280 (3): 2092–104.
doi :
10.1074/jbc.M403080200 .
PMID
15504738 .
Gorr IH, Boos D, Stemmann O (2005).
"Mutual inhibition of separase and Cdk1 by two-step complex formation" . Mol. Cell . 19 (1): 135–41.
doi :
10.1016/j.molcel.2005.05.022 .
PMID
15989971 .
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68.
doi :
10.1016/j.cell.2005.08.029 .
hdl :
11858/00-001M-0000-0010-8592-0 .
PMID
16169070 .
S2CID
8235923 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Rother K, Dengl M, Lorenz J, et al. (2007).
"Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73" . FEBS Lett . 581 (6): 1166–72.
doi :
10.1016/j.febslet.2007.02.028 .
PMID
17336302 .
S2CID
6953397 .
Bertheau P, Turpin E, Rickman DS, et al. (2007).
"Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen" . PLOS Med . 4 (3): e90.
doi :
10.1371/journal.pmed.0040090 .
PMC
1831731 .
PMID
17388661 .