From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Chondroitin sulfate synthase 1 is an
enzyme that in humans is encoded by the CHSY1
gene.
[5]
[6]
CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan
expressed on the
surface of most cells and in
extracellular matrices.
Glycosaminoglycan chains are covalently linked to a wide range of core
protein families and regulate many biologic processes, including
cell proliferation and recognition, extracellular matrix deposition, and
morphogenesis.
[7]
[6]
References
External links
Further reading
- Otsuki T, Ota T, Nishikawa T, et al. (2007).
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26.
doi:
10.1093/dnares/12.2.117.
PMID
16303743.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Clark HF, Gurney AL, Abaya E, et al. (2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70.
doi:
10.1101/gr.1293003.
PMC
403697.
PMID
12975309.
- Yada T, Sato T, Kaseyama H, et al. (2003).
"Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25.
doi:
10.1074/jbc.M304421200.
PMID
12907687.
- Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003).
"Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71.
doi:
10.1074/jbc.M302493200.
PMID
12716890.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Nagase T, Ishikawa K, Suyama M, et al. (1999).
"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70.
doi:
10.1093/dnares/6.1.63.
PMID
10231032.