CHST10

CHST10
Identifiers
Aliases	CHST10, HNK-1ST, HNK1ST, carbohydrate sulfotransferase 10
External IDs	OMIM: 606376; MGI: 2138283; HomoloGene: 21013; GeneCards: CHST10; OMA: CHST10 - orthologs
Gene location ( Human)
Chr.	Chromosome 2 (human)
End	100,417,668 bp
Gene location ( Mouse)
Chr.	Chromosome 1 (mouse)
End	38,937,242 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; lateral nuclear group of thalamus; ; middle temporal gyrus; ; frontal pole; ; Brodmann area 10; ; right frontal lobe; ; Brodmann area 9; ; secondary oocyte; ; putamen;
	Top expressed in
	lumbar subsegment of spinal cord; ; visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; central gray substance of midbrain; ; cerebellar cortex; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; HNK-1 sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	cell adhesion; carbohydrate biosynthetic process; carbohydrate metabolic process; proteoglycan biosynthetic process;
	Sources: Amigo / QuickGO
Orthologs
	9486
	98388
	ENSG00000115526
	ENSMUSG00000026080
	O43529
	Q6PGK7
	NM_004854
	NM_145142; NM_001368780
	NP_004845
	NP_660124; NP_001355709
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.^[5]^[6]

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi: 10.1074/jbc.M204907200. PMID 12080076.
^ ^a ^b "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

External links

Human CHST10 genome location and CHST10 gene details page in the UCSC Genome Browser.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi: 10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ong E, Yeh JC, Ding Y, et al. (1999). "Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis". J. Biol. Chem. 274 (36): 25608–12. doi: 10.1074/jbc.274.36.25608. PMID 10464296.
Ong E, Yeh JC, Ding Y, et al. (1998). "Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids". J. Biol. Chem. 273 (9): 5190–5. doi: 10.1074/jbc.273.9.5190. PMID 9478973.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi: 10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi: 10.1006/abio.1996.0138. PMID 8619474.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi: 10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi: 10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12080076-5] Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi: 10.1074/jbc.M204907200. PMID 12080076.

[entrez-6] "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

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