Choriogonadotropin subunit beta is a
protein that in humans is encoded by the CGB7gene.[3][4]
This gene is a member of the
glycoprotein hormone beta chain family and encodes the beta 7 subunit of
chorionic gonadotropin (CG). Glycoprotein hormones are
heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the
trophoblastic cells of the
placenta and stimulates the
ovaries to synthesize the
steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the
luteinizing hormone beta subunit gene.[4]
Weisshaar G, Hiyama J, Renwick AG (1992). "Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy". Glycobiology. 1 (4): 393–404.
doi:
10.1093/glycob/1.4.393.
PMID1820200.
Jameson JL, Lindell CM, Habener JF (1986). "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes". DNA. 5 (3): 227–34.
doi:
10.1089/dna.1986.5.227.
PMID2424697.
Talmadge K, Boorstein WR, Fiddes JC (1984). "The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone". DNA. 2 (4): 281–9.
doi:
10.1089/dna.1983.2.281.
PMID6319099.
Fiddes JC, Goodman HM (1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature. 286 (5774): 684–7.
Bibcode:
1980Natur.286..684F.
doi:
10.1038/286684a0.
PMID6774259.
S2CID4323775.
Bellet D, Lazar V, Bièche I, et al. (1997). "Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells". Cancer Res. 57 (3): 516–23.
PMID9012484.
Choriogonadotropin subunit beta is a
protein that in humans is encoded by the CGB7gene.[3][4]
This gene is a member of the
glycoprotein hormone beta chain family and encodes the beta 7 subunit of
chorionic gonadotropin (CG). Glycoprotein hormones are
heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the
trophoblastic cells of the
placenta and stimulates the
ovaries to synthesize the
steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the
luteinizing hormone beta subunit gene.[4]
Weisshaar G, Hiyama J, Renwick AG (1992). "Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy". Glycobiology. 1 (4): 393–404.
doi:
10.1093/glycob/1.4.393.
PMID1820200.
Jameson JL, Lindell CM, Habener JF (1986). "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes". DNA. 5 (3): 227–34.
doi:
10.1089/dna.1986.5.227.
PMID2424697.
Talmadge K, Boorstein WR, Fiddes JC (1984). "The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone". DNA. 2 (4): 281–9.
doi:
10.1089/dna.1983.2.281.
PMID6319099.
Fiddes JC, Goodman HM (1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature. 286 (5774): 684–7.
Bibcode:
1980Natur.286..684F.
doi:
10.1038/286684a0.
PMID6774259.
S2CID4323775.
Bellet D, Lazar V, Bièche I, et al. (1997). "Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells". Cancer Res. 57 (3): 516–23.
PMID9012484.