Choriogonadotropin subunit beta variant 1 is a
protein that in humans is encoded by the CGB1gene.[4][5]
The beta subunit of
chorionic gonadotropin (CGB) is encoded by six highly
homologous and structurally similar genes that are arranged in tandem and inverted pairs on
chromosome 19q13.3, and contiguous with the
luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranslated region. This gene was originally thought to be one of the two
pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the
polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (Dirnhofer S, Hermann M, Hittmair A, Hoermann R, Kapelari K, Berger P (December 1996).
"Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. Clin. Endocrinol. Metab. 81 (12): 4212–7.
doi:10.1210/jcem.81.12.8954017.
PMID8954017.). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[5]
Talmadge K, Boorstein WR, Fiddes JC (1984). "The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone". DNA. 2 (4): 281–9.
doi:
10.1089/dna.1983.2.281.
PMID6319099.
Giovangrandi Y, Parfait B, Asheuer M, et al. (2001). "Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays". Cancer Lett. 168 (1): 93–100.
doi:
10.1016/S0304-3835(01)00496-7.
PMID11368883.
Choriogonadotropin subunit beta variant 1 is a
protein that in humans is encoded by the CGB1gene.[4][5]
The beta subunit of
chorionic gonadotropin (CGB) is encoded by six highly
homologous and structurally similar genes that are arranged in tandem and inverted pairs on
chromosome 19q13.3, and contiguous with the
luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranslated region. This gene was originally thought to be one of the two
pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the
polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (Dirnhofer S, Hermann M, Hittmair A, Hoermann R, Kapelari K, Berger P (December 1996).
"Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. Clin. Endocrinol. Metab. 81 (12): 4212–7.
doi:10.1210/jcem.81.12.8954017.
PMID8954017.). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[5]
Talmadge K, Boorstein WR, Fiddes JC (1984). "The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone". DNA. 2 (4): 281–9.
doi:
10.1089/dna.1983.2.281.
PMID6319099.
Giovangrandi Y, Parfait B, Asheuer M, et al. (2001). "Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays". Cancer Lett. 168 (1): 93–100.
doi:
10.1016/S0304-3835(01)00496-7.
PMID11368883.