| CENPI | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300065 MGI: 2147897 HomoloGene: 4899 GeneCards: CENPI | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Centromere protein I is a protein that in humans is encoded by the CENPI gene. [5] [6]
Function
The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. [6] CENPI is a target gene of the transcription factor E2F. [7] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells. [7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102384 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031262 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi: 10.1038/ncb1396. PMID 16622420. S2CID 26974412.
- ^ a b "Entrez Gene: CENPI centromere protein I".
- ^ a b Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget. 8 (37): 62167–62182. doi: 10.18632/oncotarget.19131. PMC 5617495. PMID 28977935.
Further reading
- Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
- Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi: 10.1038/ncb1397. PMID 16622419. S2CID 205286556.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode: 2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
- Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ (April 2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology. 5 (4): 341–5. doi: 10.1038/ncb953. PMID 12640463. S2CID 33165992.
- Roberts RG, Kendall E, Vetrie D, Bobrow M (October 1996). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics. 37 (1): 122–4. doi: 10.1006/geno.1996.0528. PMID 8921378.
- Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA (February 1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein". Molecular and Cellular Endocrinology. 108 (1–2): 115–24. doi: 10.1016/0303-7207(94)03468-9. hdl: 1765/64471. PMID 7758824. S2CID 11122437.
- Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (February 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode: 1992Natur.355..632A. doi: 10.1038/355632a0. PMID 1538749. S2CID 4234345.
External links
- Human CENPI genome location and CENPI gene details page in the UCSC Genome Browser.
 | This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |
| CENPI | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300065 MGI: 2147897 HomoloGene: 4899 GeneCards: CENPI | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Centromere protein I is a protein that in humans is encoded by the CENPI gene. [5] [6]
Function
The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. [6] CENPI is a target gene of the transcription factor E2F. [7] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells. [7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102384 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031262 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi: 10.1038/ncb1396. PMID 16622420. S2CID 26974412.
- ^ a b "Entrez Gene: CENPI centromere protein I".
- ^ a b Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget. 8 (37): 62167–62182. doi: 10.18632/oncotarget.19131. PMC 5617495. PMID 28977935.
Further reading
- Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
- Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi: 10.1038/ncb1397. PMID 16622419. S2CID 205286556.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode: 2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
- Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ (April 2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology. 5 (4): 341–5. doi: 10.1038/ncb953. PMID 12640463. S2CID 33165992.
- Roberts RG, Kendall E, Vetrie D, Bobrow M (October 1996). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics. 37 (1): 122–4. doi: 10.1006/geno.1996.0528. PMID 8921378.
- Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA (February 1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein". Molecular and Cellular Endocrinology. 108 (1–2): 115–24. doi: 10.1016/0303-7207(94)03468-9. hdl: 1765/64471. PMID 7758824. S2CID 11122437.
- Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (February 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode: 1992Natur.355..632A. doi: 10.1038/355632a0. PMID 1538749. S2CID 4234345.
External links
- Human CENPI genome location and CENPI gene details page in the UCSC Genome Browser.
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| This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |