Cell division cycle protein 27 homolog is a
protein that in humans is encoded by the CDC27gene.[5][6]
Function
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of
anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the
ubiquitin-mediated
proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (
tetratricopeptide repeat), a protein domain important for
protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including
Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of
mitosis.[6]
Chen PL, Ueng YC, Durfee T, Chen KC, Yang-Feng T, Lee WH (Feb 1995). "Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner". Cell Growth & Differentiation. 6 (2): 199–210.
PMID7756179.
Ho PP, Couch FJ, Brody LC, Abel KJ, Boehnke M, Shearon TH, Chandrasekharappa SC, Collins FS, Weber BL (Sep 1995). "Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3". Somatic Cell and Molecular Genetics. 21 (5): 351–5.
doi:
10.1007/BF02257470.
hdl:2027.42/45546.
PMID8619132.
S2CID9614052.
Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P (Sep 2001). "Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex". Nature Structural Biology. 8 (9): 784–8.
doi:
10.1038/nsb0901-784.
PMID11524682.
S2CID27021761.
Cell division cycle protein 27 homolog is a
protein that in humans is encoded by the CDC27gene.[5][6]
Function
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of
anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the
ubiquitin-mediated
proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (
tetratricopeptide repeat), a protein domain important for
protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including
Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of
mitosis.[6]
Chen PL, Ueng YC, Durfee T, Chen KC, Yang-Feng T, Lee WH (Feb 1995). "Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner". Cell Growth & Differentiation. 6 (2): 199–210.
PMID7756179.
Ho PP, Couch FJ, Brody LC, Abel KJ, Boehnke M, Shearon TH, Chandrasekharappa SC, Collins FS, Weber BL (Sep 1995). "Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3". Somatic Cell and Molecular Genetics. 21 (5): 351–5.
doi:
10.1007/BF02257470.
hdl:2027.42/45546.
PMID8619132.
S2CID9614052.
Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P (Sep 2001). "Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex". Nature Structural Biology. 8 (9): 784–8.
doi:
10.1038/nsb0901-784.
PMID11524682.
S2CID27021761.