Calcium-binding tyrosine phosphorylation-regulated protein is a
protein that in humans is encoded by the CABYRgene.[5][6][7][8]
To reach fertilization competence,
spermatozoa undergo a series of morphological and molecular maturational processes, termed
capacitation, involving protein
tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm
flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A
pseudogene on
chromosome 3 has been identified for this gene.
Transcript variants of this gene encode multiple protein
isoforms. An additional transcript and isoform has not been fully characterized.[8]
Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50.
doi:
10.1016/S0165-0378(01)00103-6.
PMID11730911.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17.
doi:
10.1016/j.bbrc.2005.02.089.
PMID15752768.
Calcium-binding tyrosine phosphorylation-regulated protein is a
protein that in humans is encoded by the CABYRgene.[5][6][7][8]
To reach fertilization competence,
spermatozoa undergo a series of morphological and molecular maturational processes, termed
capacitation, involving protein
tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm
flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A
pseudogene on
chromosome 3 has been identified for this gene.
Transcript variants of this gene encode multiple protein
isoforms. An additional transcript and isoform has not been fully characterized.[8]
Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50.
doi:
10.1016/S0165-0378(01)00103-6.
PMID11730911.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17.
doi:
10.1016/j.bbrc.2005.02.089.
PMID15752768.