aarF domain containing kinase 3 is a
protein that in humans is encoded by the ADCK3gene.[5]
This gene encodes a
mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the
respiratory chain. It is not related to the family of
ABC transporter proteins. Expression of this gene is induced by the tumor suppressor
p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced
apoptosis.
Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.[5]
Iiizumi M, Arakawa H, Mori T, et al. (2002). "Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex". Cancer Res. 62 (5): 1246–50.
PMID11888884.
aarF domain containing kinase 3 is a
protein that in humans is encoded by the ADCK3gene.[5]
This gene encodes a
mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the
respiratory chain. It is not related to the family of
ABC transporter proteins. Expression of this gene is induced by the tumor suppressor
p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced
apoptosis.
Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.[5]
Iiizumi M, Arakawa H, Mori T, et al. (2002). "Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex". Cancer Res. 62 (5): 1246–50.
PMID11888884.