C19orf44 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | C19orf44, chromosome 19 open reading frame 44, Chromosome 19 open reading frame 44 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1919504; HomoloGene: 12975; GeneCards: C19orf44; OMA: C19orf44 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. [5] C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein (and gene) exists in other species besides human. The protein contains one domain of unknown function ( DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, [6] but also has significant expression in the thyroid and parathyroid. [7] Other names for this protein include: LOC84167. [8]
The entire gene is 25,416 base pairs in length, [9] and has an unprocessed mRNA that is 3,446 nucleotides in length. [6] It contains 10 exons that code for a 657 amino acid protein. There are 7 splice variants that exist for C19orf44. [10]
C19orf44 is located on the nineteenth chromosome on 19p13.11. [6]
C19orf44 has a molecular weight of 71,343 Da, [11] and an isoelectric point of 5.52. [12] The amino acid sequence for C19orf44 was found to be serine rich using tools on EMBL-EBI. [13] Additionally, there is a domain of unknown function (DUF) located from amino acid 474 to 641. [14]
C19orf44 has experimentally determined phosphorylation sites at the S114 and S213 positions. [14] Other predicted post-translational modifications were found using tools on ExPASy [15] and are shown in the protein illustration below. N-terminal acetylation is predicted at S3. There is also a predicted sumoylation motif from amino acid 212 to 221.
C19orf44 is predicted to be localized in the nucleus or cytosol. [17]
C19orf44 is shown to be expressed at low levels in various tissues throughout the body as shown by NCBI's EST Profile. [18] It most highly expressed in the testis and ovary, [6] but also has significant expression in the thyroid and parathyroid. [7] C19orf44 is expressed in all stages of development, except for in infants. There is an increased expression of C19orf44 in a developing fetus. [18]
Orthologs of C19orf44 have been found in most mammals and a select few other vertebrates and invertebrates. Multiple sequence alignments using ClustalW [19] provided evidence that the DUF in C19orf44 is highly conserved in its orthologs. The table below represents a small selection of the orthologs found using NCBI Blast. [20]
Genus and Species | Common Name | Accession Number (from NCBI [21]) | Divergence (MYA) [22] | Sequence Identity (%) [23] |
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Rhinopithecus roxellana | Golden Snub-nosed Monkey | XP_010359783.1 | 29 | 86.9 |
Orcinus orca | Killer Whale | XP_004277754.1 | 96 | 83.2 |
Sus scrofa | Wild Boar | XP_005661251.2 | 96 | 60.1 |
Monodelphis domestica | Opossum | XP_007489796.1 | 159 | 45.5 |
Chelonia mydas | Green Sea Turtle | XP_007072179.1 | 312 | 35.2 |
Astyanax mexicanus | Mexican Tetra | XP_007246256.2 | 435 | 28.2 |
Mizuhopecten yessoensis | Scallop | XP_021343742.1 | 797 | 24.4 |
There are no paralogs for C19orf44 in Homo sapiens.
C19orf44 has been found to interact with various proteins from the two-hybrid screening method. Interactions with Hsp90 co-chaperone ( CDC37), [24] and spermatid associated protein (SPERT) [25] have been found.
C19orf44 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | C19orf44, chromosome 19 open reading frame 44, Chromosome 19 open reading frame 44 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1919504; HomoloGene: 12975; GeneCards: C19orf44; OMA: C19orf44 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. [5] C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein (and gene) exists in other species besides human. The protein contains one domain of unknown function ( DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, [6] but also has significant expression in the thyroid and parathyroid. [7] Other names for this protein include: LOC84167. [8]
The entire gene is 25,416 base pairs in length, [9] and has an unprocessed mRNA that is 3,446 nucleotides in length. [6] It contains 10 exons that code for a 657 amino acid protein. There are 7 splice variants that exist for C19orf44. [10]
C19orf44 is located on the nineteenth chromosome on 19p13.11. [6]
C19orf44 has a molecular weight of 71,343 Da, [11] and an isoelectric point of 5.52. [12] The amino acid sequence for C19orf44 was found to be serine rich using tools on EMBL-EBI. [13] Additionally, there is a domain of unknown function (DUF) located from amino acid 474 to 641. [14]
C19orf44 has experimentally determined phosphorylation sites at the S114 and S213 positions. [14] Other predicted post-translational modifications were found using tools on ExPASy [15] and are shown in the protein illustration below. N-terminal acetylation is predicted at S3. There is also a predicted sumoylation motif from amino acid 212 to 221.
C19orf44 is predicted to be localized in the nucleus or cytosol. [17]
C19orf44 is shown to be expressed at low levels in various tissues throughout the body as shown by NCBI's EST Profile. [18] It most highly expressed in the testis and ovary, [6] but also has significant expression in the thyroid and parathyroid. [7] C19orf44 is expressed in all stages of development, except for in infants. There is an increased expression of C19orf44 in a developing fetus. [18]
Orthologs of C19orf44 have been found in most mammals and a select few other vertebrates and invertebrates. Multiple sequence alignments using ClustalW [19] provided evidence that the DUF in C19orf44 is highly conserved in its orthologs. The table below represents a small selection of the orthologs found using NCBI Blast. [20]
Genus and Species | Common Name | Accession Number (from NCBI [21]) | Divergence (MYA) [22] | Sequence Identity (%) [23] |
---|---|---|---|---|
Rhinopithecus roxellana | Golden Snub-nosed Monkey | XP_010359783.1 | 29 | 86.9 |
Orcinus orca | Killer Whale | XP_004277754.1 | 96 | 83.2 |
Sus scrofa | Wild Boar | XP_005661251.2 | 96 | 60.1 |
Monodelphis domestica | Opossum | XP_007489796.1 | 159 | 45.5 |
Chelonia mydas | Green Sea Turtle | XP_007072179.1 | 312 | 35.2 |
Astyanax mexicanus | Mexican Tetra | XP_007246256.2 | 435 | 28.2 |
Mizuhopecten yessoensis | Scallop | XP_021343742.1 | 797 | 24.4 |
There are no paralogs for C19orf44 in Homo sapiens.
C19orf44 has been found to interact with various proteins from the two-hybrid screening method. Interactions with Hsp90 co-chaperone ( CDC37), [24] and spermatid associated protein (SPERT) [25] have been found.