Carl David Gutsche (March 21, 1921 – August 28, 2018) was an American chemist.

Gutsche was raised in La Grange Park, Illinois. He studied at Oberlin College and later earned a doctorate in organic chemistry from the University of Wisconsin. Gutsche taught at Washington University in St. Louis from 1947 to 1989 earning the rank of professor emeritus. ^[1] From 1989 to 2002, he was appointed Robert A. Welch Professor of Chemistry at Texas Christian University. Upon retirement in 2002, Gutsche moved to Tucson, Arizona and became a visiting scholar at the University of Arizona. ^{[1] [2]}