Clinical data | |
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Pronunciation | /bəˈnæzəprɪl/ |
Trade names | Lotensin, others |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a692011 |
License data |
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Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 96.7% |
Metabolism | Liver glucuronidation |
Elimination half-life | 10-11 hours |
Excretion | Kidney and bile duct |
Identifiers | |
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CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C24H28N2O5 |
Molar mass | 424.497 g·mol−1 |
3D model ( JSmol) | |
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(verify) |
Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [2] It is a reasonable initial treatment for high blood pressure. [2] It is taken by mouth. [2] Versions are available as the combinations benazepril/ hydrochlorothiazide and benazepril/amlodipine. [2]
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing. [2] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema. [2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe. [3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity. [2]
Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication. [2] In 2021, it was the 147th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [4] [5]
Lotensin is indicated for the treatment of hypertension, to lower blood pressure. [1] [2]
The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated. [6]
Benazepril can harm the fetus. [7]
It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).
Under the brand names Fortekor ( Novartis) [8] and VetACE (Jurox Animal Health), [9] benazepril is used to treat congestive heart failure in dogs [10] [11] and chronic kidney failure in cats and dogs. [12]
Clinical data | |
---|---|
Pronunciation | /bəˈnæzəprɪl/ |
Trade names | Lotensin, others |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a692011 |
License data |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 96.7% |
Metabolism | Liver glucuronidation |
Elimination half-life | 10-11 hours |
Excretion | Kidney and bile duct |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C24H28N2O5 |
Molar mass | 424.497 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(verify) |
Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [2] It is a reasonable initial treatment for high blood pressure. [2] It is taken by mouth. [2] Versions are available as the combinations benazepril/ hydrochlorothiazide and benazepril/amlodipine. [2]
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing. [2] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema. [2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe. [3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity. [2]
Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication. [2] In 2021, it was the 147th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [4] [5]
Lotensin is indicated for the treatment of hypertension, to lower blood pressure. [1] [2]
The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated. [6]
Benazepril can harm the fetus. [7]
It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).
Under the brand names Fortekor ( Novartis) [8] and VetACE (Jurox Animal Health), [9] benazepril is used to treat congestive heart failure in dogs [10] [11] and chronic kidney failure in cats and dogs. [12]