Blood smear showing red blood cells with basophilic stippling
Basophilic stippling, also known as punctate basophilia, is the presence of numerous
basophilic granules that are dispersed through the
cytoplasm of
erythrocytes in a peripheral blood smear. They can be demonstrated to be
RNA. They are composed of aggregates of
ribosomes; degenerating
mitochondria and
siderosomes may be included in the aggregates.[citation needed] In contrast to
Pappenheimer bodies, they are negative with
Perls' acid ferrocyanide stain for iron (i.e. no iron in basophilic stippling).[1] Basophilic stippling is indicative of disturbed
erythropoiesis. It can also be found in some normal individuals.[2]
Associated conditions
Thalassemia[3] (β-thalassemia Minor (i.e. Trait) & Major, and α-thalassemia, only when 3 gene loci defective: (--/-α))
^Le, Tao; Bhushan, Vikas; Coleman, Caroline; Jones, Stepanie; Kaparaliotis, Panagiotis; Kallianos, Kimberly, eds. (2023). First Aid for the® USMLE® Step 1 2023 (33rd ed.). New York Chicago San Francisco: McGraw Hill. p. 422.
ISBN978-1-264-94662-4.
^Cheson, B. D; Rom, W. N; Webber, R. C (1984). "Basophilic stippling of red blood cells: A nonspecific finding of multiple etiology". American Journal of Industrial Medicine. 5 (4): 327–34.
doi:
10.1002/ajim.4700050409.
PMID6202140.
^Seip, M (1999). "Pyrimidine-5'-nucleotidase deficiency--congenital hemolytic anemia with basophilic stippling of erythrocytes". Tidsskrift for den Norske Laegeforening. 119 (20): 2996–8.
PMID10504847.
Blood smear showing red blood cells with basophilic stippling
Basophilic stippling, also known as punctate basophilia, is the presence of numerous
basophilic granules that are dispersed through the
cytoplasm of
erythrocytes in a peripheral blood smear. They can be demonstrated to be
RNA. They are composed of aggregates of
ribosomes; degenerating
mitochondria and
siderosomes may be included in the aggregates.[citation needed] In contrast to
Pappenheimer bodies, they are negative with
Perls' acid ferrocyanide stain for iron (i.e. no iron in basophilic stippling).[1] Basophilic stippling is indicative of disturbed
erythropoiesis. It can also be found in some normal individuals.[2]
Associated conditions
Thalassemia[3] (β-thalassemia Minor (i.e. Trait) & Major, and α-thalassemia, only when 3 gene loci defective: (--/-α))
^Le, Tao; Bhushan, Vikas; Coleman, Caroline; Jones, Stepanie; Kaparaliotis, Panagiotis; Kallianos, Kimberly, eds. (2023). First Aid for the® USMLE® Step 1 2023 (33rd ed.). New York Chicago San Francisco: McGraw Hill. p. 422.
ISBN978-1-264-94662-4.
^Cheson, B. D; Rom, W. N; Webber, R. C (1984). "Basophilic stippling of red blood cells: A nonspecific finding of multiple etiology". American Journal of Industrial Medicine. 5 (4): 327–34.
doi:
10.1002/ajim.4700050409.
PMID6202140.
^Seip, M (1999). "Pyrimidine-5'-nucleotidase deficiency--congenital hemolytic anemia with basophilic stippling of erythrocytes". Tidsskrift for den Norske Laegeforening. 119 (20): 2996–8.
PMID10504847.