Bacteriophage pRNA | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of Phage_pRNA | |
Identifiers | |
Symbol | Phage_pRNA |
Rfam | RF00044 |
Other data | |
RNA type | Gene |
Domain(s) | Viruses |
SO | SO:0000655 |
PDB structures | PDBe |
Bacteriophage pRNA is a ncRNA element. During replication of linear dsDNA viruses, the viral genome is packaged into the pre-formed viral procapsid. The packaging of DNA into the procapsid requires a molecular motor, which uses ATP as energy to accomplish the energetically unfavorable motion. In some bacteriophage, an RNA (pRNA) molecule is a vital component of this motor. [1] Structural analyses of the packaging motor have demonstrated that the pRNA molecule has fivefold symmetry when attached to the prohead. [2] [3] [4] The pRNA is thought to be bound by the capsid connector protein. [4] Only the first 120 bases of the pRNA are essential for packing the viral DNA. [5] [6] The pRNA is proposed to be composed of two domains, one corresponding to the first 120 bases and the second to the remaining 50 bases. [6] Nuclear cleavage occurs in the single strand region linking these two domains. [6]
{{
cite book}}
: |journal=
ignored (
help)
Bacteriophage pRNA | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of Phage_pRNA | |
Identifiers | |
Symbol | Phage_pRNA |
Rfam | RF00044 |
Other data | |
RNA type | Gene |
Domain(s) | Viruses |
SO | SO:0000655 |
PDB structures | PDBe |
Bacteriophage pRNA is a ncRNA element. During replication of linear dsDNA viruses, the viral genome is packaged into the pre-formed viral procapsid. The packaging of DNA into the procapsid requires a molecular motor, which uses ATP as energy to accomplish the energetically unfavorable motion. In some bacteriophage, an RNA (pRNA) molecule is a vital component of this motor. [1] Structural analyses of the packaging motor have demonstrated that the pRNA molecule has fivefold symmetry when attached to the prohead. [2] [3] [4] The pRNA is thought to be bound by the capsid connector protein. [4] Only the first 120 bases of the pRNA are essential for packing the viral DNA. [5] [6] The pRNA is proposed to be composed of two domains, one corresponding to the first 120 bases and the second to the remaining 50 bases. [6] Nuclear cleavage occurs in the single strand region linking these two domains. [6]
{{
cite book}}
: |journal=
ignored (
help)