| BPD_transp_1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BPD_transp_1 | ||||||||
| Pfam | PF00528 | ||||||||
| Pfam clan | CL0404 | ||||||||
| InterPro | IPR000515 | ||||||||
| PROSITE | PDOC00364 | ||||||||
| TCDB | 3.A.1 | ||||||||
| OPM superfamily | 17 | ||||||||
| OPM protein | 3puz | ||||||||
| |||||||||
Bacterial binding protein-dependent transport systems, [1] [2] are multicomponent systems typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system. The integral inner-membrane proteins translocate the substrate across the membrane. It has been shown, [3] [4] that most of these proteins contain a conserved region located about 80 to 100 residues from their C-terminal extremity. This region seems [5] to be located in a cytoplasmic loop between two transmembrane domains. Apart from the conserved region, the sequence of these proteins is quite divergent, and they have a variable number of transmembrane helices, however they can be classified into seven families which have been respectively termed: araH, cysTW, fecCD, hisMQ, livHM, malFG and oppBC.
References
- ^ Ames GF (1986). "Bacterial periplasmic transport systems: structure, mechanism, and evolution". Annu. Rev. Biochem. 55: 397–425. doi: 10.1146/annurev.bi.55.070186.002145. PMID 3527048.
- ^ Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher MP (August 1990). "Binding protein-dependent transport systems". J. Bioenerg. Biomembr. 22 (4): 571–92. doi: 10.1007/BF00762962. PMID 2229036. S2CID 29046676.
- ^ Dassa E, Hofnung M (September 1985). "Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems". EMBO J. 4 (9): 2287–93. doi: 10.1002/j.1460-2075.1985.tb03928.x. PMC 554499. PMID 3000770.
- ^ Saurin W, Kaster W, Dassa E (June 1994). "Bacterial binding protein-dependent permeases: characterization of distinctive signatures for functionally related integral cytoplasmic membrane proteins". Mol. Microbiol. 12 (6): 993–1004. doi: 10.1111/j.1365-2958.1994.tb01087.x. PMID 7934906. S2CID 889103.
- ^ Pearce SR, Mimmack ML, Gallagher MP, Gileadi U, Hyde SC, Higgins CF (January 1992). "Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium". Mol. Microbiol. 6 (1): 47–57. doi: 10.1111/j.1365-2958.1992.tb00836.x. PMID 1738314. S2CID 1660114.
| BPD_transp_1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BPD_transp_1 | ||||||||
| Pfam | PF00528 | ||||||||
| Pfam clan | CL0404 | ||||||||
| InterPro | IPR000515 | ||||||||
| PROSITE | PDOC00364 | ||||||||
| TCDB | 3.A.1 | ||||||||
| OPM superfamily | 17 | ||||||||
| OPM protein | 3puz | ||||||||
| |||||||||
Bacterial binding protein-dependent transport systems, [1] [2] are multicomponent systems typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system. The integral inner-membrane proteins translocate the substrate across the membrane. It has been shown, [3] [4] that most of these proteins contain a conserved region located about 80 to 100 residues from their C-terminal extremity. This region seems [5] to be located in a cytoplasmic loop between two transmembrane domains. Apart from the conserved region, the sequence of these proteins is quite divergent, and they have a variable number of transmembrane helices, however they can be classified into seven families which have been respectively termed: araH, cysTW, fecCD, hisMQ, livHM, malFG and oppBC.
References
- ^ Ames GF (1986). "Bacterial periplasmic transport systems: structure, mechanism, and evolution". Annu. Rev. Biochem. 55: 397–425. doi: 10.1146/annurev.bi.55.070186.002145. PMID 3527048.
- ^ Higgins CF, Hyde SC, Mimmack MM, Gileadi U, Gill DR, Gallagher MP (August 1990). "Binding protein-dependent transport systems". J. Bioenerg. Biomembr. 22 (4): 571–92. doi: 10.1007/BF00762962. PMID 2229036. S2CID 29046676.
- ^ Dassa E, Hofnung M (September 1985). "Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems". EMBO J. 4 (9): 2287–93. doi: 10.1002/j.1460-2075.1985.tb03928.x. PMC 554499. PMID 3000770.
- ^ Saurin W, Kaster W, Dassa E (June 1994). "Bacterial binding protein-dependent permeases: characterization of distinctive signatures for functionally related integral cytoplasmic membrane proteins". Mol. Microbiol. 12 (6): 993–1004. doi: 10.1111/j.1365-2958.1994.tb01087.x. PMID 7934906. S2CID 889103.
- ^ Pearce SR, Mimmack ML, Gallagher MP, Gileadi U, Hyde SC, Higgins CF (January 1992). "Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium". Mol. Microbiol. 6 (1): 47–57. doi: 10.1111/j.1365-2958.1992.tb00836.x. PMID 1738314. S2CID 1660114.