Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, intestine and stomach expression 1 (MIST-1) is a
protein that in humans is encoded by the BHLHA15
gene.[5][6][7]
Function
bHLHa15 is required developmentally for the proper organization of all protein secreting, serous
exocrine glands. In the absence of Mist1, exocrine tissue shows improper organization of
organelles, especially the localization of the
zymogen granules. The zymogen granules are the
vesicles that store enzymes near the
plasma membrane for easy release when stimulated. This disorganization caused by the loss of Mist1 leads to increased susceptibility toward
pancreatic damage and potentially
pancreatic cancer.
Pin CL, Lemercier C, Konieczny SF (2000). "Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3". Cytogenet. Cell Genet. 86 (3–4): 219–22.
doi:
10.1159/000015342.
PMID10575209.
S2CID42840963.
Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, intestine and stomach expression 1 (MIST-1) is a
protein that in humans is encoded by the BHLHA15
gene.[5][6][7]
Function
bHLHa15 is required developmentally for the proper organization of all protein secreting, serous
exocrine glands. In the absence of Mist1, exocrine tissue shows improper organization of
organelles, especially the localization of the
zymogen granules. The zymogen granules are the
vesicles that store enzymes near the
plasma membrane for easy release when stimulated. This disorganization caused by the loss of Mist1 leads to increased susceptibility toward
pancreatic damage and potentially
pancreatic cancer.
Pin CL, Lemercier C, Konieczny SF (2000). "Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3". Cytogenet. Cell Genet. 86 (3–4): 219–22.
doi:
10.1159/000015342.
PMID10575209.
S2CID42840963.