Beclin-1 is a
protein that in humans is encoded by the BECN1gene.[5][6] Beclin-1 is a mammalian
ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the
C. elegansnematode.[7] This protein interacts with either
BCL-2 or
PI3k class III, playing a critical role in the regulation of both
autophagy and
cell death.
Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of those affected, which causes diminished
autophagy which in turn results in increased neuronal cell death.[10]
Rommens JM, Durocher F, McArthur J, Tonin P, LeBlanc JF, Allen T, et al. (August 1995). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42.
doi:
10.1006/geno.1995.1185.
PMID7490091.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Liang XH, Yu J, Brown K, Levine B (April 2001). "Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function". Cancer Research. 61 (8): 3443–9.
PMID11309306.
Beclin-1 is a
protein that in humans is encoded by the BECN1gene.[5][6] Beclin-1 is a mammalian
ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the
C. elegansnematode.[7] This protein interacts with either
BCL-2 or
PI3k class III, playing a critical role in the regulation of both
autophagy and
cell death.
Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of those affected, which causes diminished
autophagy which in turn results in increased neuronal cell death.[10]
Rommens JM, Durocher F, McArthur J, Tonin P, LeBlanc JF, Allen T, et al. (August 1995). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42.
doi:
10.1006/geno.1995.1185.
PMID7490091.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Liang XH, Yu J, Brown K, Levine B (April 2001). "Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function". Cancer Research. 61 (8): 3443–9.
PMID11309306.