Bcl-2-like protein 12 is a
protein that in humans is encoded by the BCL2L12gene.[5][6]
The
protein encoded by this gene belongs to the
Bcl-2 protein family. Bcl-2 family members form
hetero- or
homodimers and act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two
alternatively splicedtranscript variants of this gene encoding distinct
isoforms have been reported.[5]
Bcl2L12 expression is upregulated in most human
glioblastomas. Expression of Bcl2L12 results in resistance to
apoptosis. Bcl2L12 directly neutralizes caspase-7 (
CASP7) and indirectly neutralizes caspase-3 (
CASP3) by an indirect mechanism.[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.[8]
^Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21.
doi:
10.1006/geno.2000.6455.
PMID11401436.
Scorilas A, Kyriakopoulou L, Yousef GM, et al. (2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21.
doi:
10.1006/geno.2000.6455.
PMID11401436.
Talieri M, Diamandis EP, Katsaros N, et al. (2004). "Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors". Thromb. Haemost. 89 (6): 1081–8.
doi:
10.1055/s-0037-1613411.
PMID12783122.
S2CID44619207.
Mathioudaki K, Scorilas A, Papadokostopoulou A, et al. (2005). "Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer". Biol. Chem. 385 (9): 779–83.
doi:
10.1515/BC.2004.101.
PMID15493871.
S2CID33174333.
Bcl-2-like protein 12 is a
protein that in humans is encoded by the BCL2L12gene.[5][6]
The
protein encoded by this gene belongs to the
Bcl-2 protein family. Bcl-2 family members form
hetero- or
homodimers and act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two
alternatively splicedtranscript variants of this gene encoding distinct
isoforms have been reported.[5]
Bcl2L12 expression is upregulated in most human
glioblastomas. Expression of Bcl2L12 results in resistance to
apoptosis. Bcl2L12 directly neutralizes caspase-7 (
CASP7) and indirectly neutralizes caspase-3 (
CASP3) by an indirect mechanism.[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.[8]
^Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21.
doi:
10.1006/geno.2000.6455.
PMID11401436.
Scorilas A, Kyriakopoulou L, Yousef GM, et al. (2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21.
doi:
10.1006/geno.2000.6455.
PMID11401436.
Talieri M, Diamandis EP, Katsaros N, et al. (2004). "Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors". Thromb. Haemost. 89 (6): 1081–8.
doi:
10.1055/s-0037-1613411.
PMID12783122.
S2CID44619207.
Mathioudaki K, Scorilas A, Papadokostopoulou A, et al. (2005). "Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer". Biol. Chem. 385 (9): 779–83.
doi:
10.1515/BC.2004.101.
PMID15493871.
S2CID33174333.