BRCA2 and CDKN1A-interacting protein is a
protein that is encoded by the BCCIPgene in humans.[5][6][7]
This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]
Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene. 302 (1–2): 139–46.
doi:
10.1016/S0378-1119(02)01098-3.
PMID12527204.
BRCA2 and CDKN1A-interacting protein is a
protein that is encoded by the BCCIPgene in humans.[5][6][7]
This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]
Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene. 302 (1–2): 139–46.
doi:
10.1016/S0378-1119(02)01098-3.
PMID12527204.