From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Deltex E3 ubiquitin ligase 3L is a
protein that in humans is encoded by the DTX3L
gene.
[5]
Function
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).
References
Further reading
- Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003).
"The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7.
doi:
10.1074/jbc.M301157200.
PMID
12670957.
- Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA (2006).
"BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate". Mol. Cell. Biol. 26 (14): 5348–59.
doi:
10.1128/MCB.02351-05.
PMC
1592708.
PMID
16809771.
- Wilting SM, de Wilde J, Meijer CJ, Berkhof J, Yi Y, van Wieringen WN, Braakhuis BJ, Meijer GA, Ylstra B, Snijders PJ, Steenbergen RD (2008).
"Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer". Genes Chromosomes Cancer. 47 (10): 890–905.
doi:
10.1002/gcc.20590.
PMC
2733213.
PMID
18618715.
- Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA (2009).
"BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response". Mol. Cell. 36 (1): 110–20.
doi:
10.1016/j.molcel.2009.08.019.
PMC
2913878.
PMID
19818714.
- Obiero J, Walker JR, Dhe-Paganon S (2012). "Fold of the conserved DTC domain in Deltex proteins". Proteins. 80 (5): 1495–9.
doi:
10.1002/prot.24054.
PMID
22411408.
S2CID
40043949.
- Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp MA (2013).
"BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8". Mol. Cell. Biol. 33 (4): 845–57.
doi:
10.1128/MCB.00990-12.
PMC
3571337.
PMID
23230272.
- Holleman J, Marchese A (2014).
"The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4". Mol. Biol. Cell. 25 (12): 1892–904.
doi:
10.1091/mbc.E13-10-0612.
PMC
4055268.
PMID
24790097.
This article incorporates text from the
United States National Library of Medicine, which is in the
public domain.