Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. [1]
Arias-Stella reaction is due to progesterone primarily. Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer. [1]
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions. [1]
Five subtypes are recognized: [1]
It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954. [2]
Molar ectopic
Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. [1]
Arias-Stella reaction is due to progesterone primarily. Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer. [1]
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions. [1]
Five subtypes are recognized: [1]
It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954. [2]
Molar ectopic